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Titolo:
Analysis of type 1 fimbriae expression in verotoxigenic Escherichia coli: a comparison between serotypes O157 and O26
Autore:
Roe, AJ; Currie, C; Smith, DGE; Gally, DL;
Indirizzi:
Univ Edinburgh, Zoonot & Anim Pathogens Res Lab, Edinburgh EH8 9AG, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9AG Midlothian, Scotland
Titolo Testata:
MICROBIOLOGY-UK
, volume: 147, anno: 2001,
parte:, 1
pagine: 145 - 152
SICI:
1350-0872(200101)147:<145:AOT1FE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLS PHASE VARIATION; FIM SWITCH; H-NS; K-12; GENE; PATHOGENESIS; TEMPERATURE; INFECTIONS; RESERVOIR; SEQUENCE;
Keywords:
Escherichia coli O157; VTEC; type 1 fimbriae; phase variation; adherence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Gally, DL Univ Edinburgh, Zoonot & Anim Pathogens Res Lab, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland Univ Edinburgh Teviot Pl Edinburgh Midlothian Scotland EH8 9AG d
Citazione:
A.J. Roe et al., "Analysis of type 1 fimbriae expression in verotoxigenic Escherichia coli: a comparison between serotypes O157 and O26", MICROBIO-UK, 147, 2001, pp. 145-152

Abstract

Previous research has shown that verotoxin-producing Escherichia coli (VTEC) O157 strains appear unable to express type 1 fimbriae although other serotypes such as O26 and O118 can. This study has investigated the molecular basis of this difference. The study confirmed the presence of a 16 bp deletion within the regulatory region of fimA (fim switch) in 63 VTEC O157 strains but not in other VTEC serotypes tested. The firn switch was shown to be detectable only in the phase off orientation in VTEC O157. but detection ofthe switch in the phase on orientation correlated with the degree of mannose-sensitive yeast agglutination in VTEC 026. Repair of the 16 bp deletion in the VTEC O157 fim switch region restored phase-variable expression of fimA in a permissive background. Non-O157 VTEC, especially O26 and O118, can be pathogenic in cattle; the role of type 1 fimbriae in this and colonization is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:32:31