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Titolo:
Hemadsorption expressed by cloned H genes from subacute sclerosing panencephalitis (SSPE) viruses and their possible progenitor measles viruses isolated in Osaka, Japan
Autore:
Furukawa, K; Ayata, M; Kimura, M; Seto, T; Matsunaga, I; Murata, R; Yamano, T; Ogura, H;
Indirizzi:
Osaka City Univ, Sch Med, Dept Virol, Abeno Ku, Osaka 5458585, Japan OsakaCity Univ Osaka Japan 5458585 irol, Abeno Ku, Osaka 5458585, Japan Osaka City Univ, Sch Med, Biophys Lab, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 d, Biophys Lab, Osaka 5458585, Japan Osaka City Univ, Sch Med, Dept Pediat, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 d, Dept Pediat, Osaka 5458585, Japan Environm & Publ Hlth Bur City Osaka, Osaka 5308201, Japan Environm & Publ Hlth Bur City Osaka Osaka Japan 5308201 a 5308201, Japan
Titolo Testata:
MICROBIOLOGY AND IMMUNOLOGY
fascicolo: 1, volume: 45, anno: 2001,
pagine: 59 - 68
SICI:
0385-5600(2001)45:1<59:HEBCHG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
2 SIBLING VIRUSES; CELL-FUSION; HEMAGGLUTININ PROTEIN; EDMONSTON STRAIN; DOWN-REGULATION; RECEPTOR CD46; MATRIX GENE; WILD-TYPE; BRAIN; INFECTION;
Keywords:
measles virus; SSPE virus; H gene; hemadsorption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ogura, H Osaka City Univ, Sch Med, Dept Virol, Abeno Ku, Asahimachi 1-4-3,Osaka 5458585, Japan Osaka City Univ Asahimachi 1-4-3 Osaka Japan 54585858585, Japan
Citazione:
K. Furukawa et al., "Hemadsorption expressed by cloned H genes from subacute sclerosing panencephalitis (SSPE) viruses and their possible progenitor measles viruses isolated in Osaka, Japan", MICROB IMMU, 45(1), 2001, pp. 59-68

Abstract

Most subacute sclerosing panencephalitis (SSPE) viruses, including our Osaka-1, -2, and -3 strains isolated in Osaka, have shown negative hemadsorption (HAD) by African green monkey red blood cells. This property has been thought to be characteristic of SSPE virus as compared to the positive reaction of the standard Edmonston strain of measles virus (MV), However, this assumption has become quite obscure because MV mutates frequently at the genetic level during its multiplication and also because recent field strains isolated by lymphoblastoid cell lines have shown negative HAD. To investigate the above issue, the nucleotide sequences of the hemagglutinin (H) genes from SSPE virus Osaka-1, -2, or -3 strains were compared to those of various MV field strains isolated in Osaka by Vero cells. The H gene sequences ofthree SSPE strains were relatively conserved without such biased hypermutation as had been observed in the matrix (M) gene of three SSPE strains. However, this analysis of the H gene sequence of the SSPE viruses enabled us to deduce possible progenitor MVs, which are in agreement with the deductionfrom the M gene analysis we reported previously. The HAD of Vero cells transfected with the cloned H cDNAs from the SSPE strains and their progenitors suggested that negative HAD of the SSPE viruses has been maintained as one of original properties of the progenitor MVs rather than having been acquired as an altered one during long-term persistent infection in the brains of patients with SSPE.

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Documento generato il 20/01/21 alle ore 01:16:31