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Titolo:
Lipoprotein distribution of apolipoprotein C-III and its relationship to the presence in plasma of triglyceride-rich remnant lipoproteins
Autore:
Marcoux, C; Tremblay, M; Fredenrich, A; Davignon, J; Cohn, JS;
Indirizzi:
Clin Res Inst Montreal, Hyperlipidemia & Atherosclerosis Res Grp, Montreal, PQ H2W 1R7, Canada Clin Res Inst Montreal Montreal PQ Canada H2W 1R7 eal, PQ H2W 1R7, Canada
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 1, volume: 50, anno: 2001,
pagine: 112 - 119
SICI:
0026-0495(200101)50:1<112:LDOACA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; NON-EQUILIBRATING POOLS; HYPERLIPIDEMIC SUBJECTS; TRANSGENIC MICE; BYPASS GRAFTS; HUMAN-SERUM; LIPASE; RECEPTOR; HYPERTRIGLYCERIDEMIA; CHOLESTEROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Cohn, JS Clin Res Inst Montreal, Hyperlipidemia & Atherosclerosis Res Grp,110 PineAve W, Montreal, PQ H2W 1R7, Canada Clin Res Inst Montreal 110 Pine Ave W Montreal PQ Canada H2W 1R7
Citazione:
C. Marcoux et al., "Lipoprotein distribution of apolipoprotein C-III and its relationship to the presence in plasma of triglyceride-rich remnant lipoproteins", METABOLISM, 50(1), 2001, pp. 112-119

Abstract

The distribution of apolipoprotein C-III(apoC-III) between high-density lipoprotein (HDL) and apoB-containing lipoproteins has been used in lipid-lowering angiographic trials to establish a link between impaired triglyceride(TG) rich lipoprotein (TRL) metabolism and the progression of coronary artery disease. To investigate the extent to which plasma lipoprotein apoC-IIIlevels reflect the presence in plasma of potentially atherogenic remnant lipoproteins, we studied 4 groups of subjects: (1) normolipidemic (NL n = 10), (2) hypercholesterolemic (HC,type IIa, low-density lipoprotein cholesterol [LDL-C] > 3.4 mmol/L n = 10), (3) hypertriglyceridemic (HTG, type IV, TG> 2.3 mmol/L, n = 10), and (4) combined hyperlipidemic (CHL, type IIb, TG > 2.3 mmol/L, LDL-C > 3.4 mmol/L n = 10). The apoC-III level was measured in plasma lipoproteins separated either by density (ultracentrifugation) or by size (fast protein liquid chromatography [FPLC]), and was compared with 4 parameters reflecting remnant lipoprotein levels lie, very-low-density lipoprotein cholesterol [VLDL-C], intermediate-density lipoprotein cholesterol [IDL-C], remnant-like particle cholesterol [RLP-C], and intermediate-sized lipoprotein [ISL] apoE). Our results demonstrate that (1) increased amounts of apoC-III associated with plasma VLDL, TRL, or apoB-containing lipoproteins (LpB), as well as increased levels of TRL remnant lipoproteins, are acharacteristic of HTG patients rather than patients with increased LDI and[2) plasma levels of apoC-III in VLDL, TRL or LpB, as well as the HDL apoC-III to LpB apoC-III ratios, are strongly correlated with circulating levels of TRL although these apoC-III parameters more closely reflect the balance between TRL TG production and lipolysis than the extent of plasma TRL remnant accumulation. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:00:13