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Titolo:
Increased vascular endothelin-1 gene expression with unaltered nitric oxide synthase levels in fructose-induced hypertensive rats
Autore:
Lee, DH; Lee, J; Kang, DG; Paek, YW; Chung, DJ; Chung, MY;
Indirizzi:
Chonnam Natl Univ, Sch Med, Dept Internal Med, Kwangju 501757, South KoreaChonnam Natl Univ Kwangju South Korea 501757 Kwangju 501757, South Korea Chonnam Natl Univ, Sch Med, Dept Physiol, Kwangju 501757, South Korea Chonnam Natl Univ Kwangju South Korea 501757 Kwangju 501757, South Korea
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 1, volume: 50, anno: 2001,
pagine: 74 - 78
SICI:
0026-0495(200101)50:1<74:IVEGEW>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE VASODILATION; INSULIN-RESISTANCE; CELLS; RELEASE; HYPERTRIGLYCERIDEMIA; ACETYLCHOLINE; SENSITIVITY; RECEPTORS; ARTERIES; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, MY Chonnam Natl Univ, Sch Med, Dept Internal Med, 8 Hak Dong, Kwangju 501757,South Korea Chonnam Natl Univ 8 Hak Dong Kwangju South Korea 501757 h Korea
Citazione:
D.H. Lee et al., "Increased vascular endothelin-1 gene expression with unaltered nitric oxide synthase levels in fructose-induced hypertensive rats", METABOLISM, 50(1), 2001, pp. 74-78

Abstract

The present study aimed to investigate whether altered expression levels of endothelin-1 (ET-1) and nitric oxide synthase (NOS) are related to the development of insulin-resistant hypertension, Male Sprague-Dawley rats were fed a fructose-rich diet for 5 weeks. Systolic blood pressure significantlyincreased in fructose-fed rats. While serum free fatty acid (FFA) and plasma nitrite/nitrate (NOx) levels did not significantly differ between the fructose-fed and control groups, plasma insulin and serum triglyceride (TG) concentrations significantly increased in the former. ET-1 mRNA expression in the aorta increased to 195% in fructose-fed rats. Neither the protein expression of constitutive NOS (cNOS) nor that of inducible NOS (iNOS) were significantly affected by fructose feeding. However, NOx levels in the aorta were significantly increased. These results indicate that an increased expression of vascular ET-1 may be causally related to the development of hypertension in fructose-fed rats. However, an altered role of the vascular nitric oxide (NO) pathway may not be primarily involved in the development of fructose-induced hypertension, Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:55:06