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Titolo:
Taurine and osmoregulation: Platelet taurine content, uptake, and release in type 2 diabetic patients
Autore:
De Luca, G; Calpona, PR; Caponetti, A; Romano, G; Di Benedetto, A; Cucinotta, D; Di Giorgio, RM;
Indirizzi:
Policlin Univ Torre Biol, Ist Sci Biochim & Biochim Clin, I-98125 Gazzi, ME, Italy Policlin Univ Torre Biol Gazzi ME Italy I-98125 I-98125 Gazzi, ME, Italy Univ Messina, Sch Med, Dept Internal Med, Messina, Italy Univ Messina Messina Italy , Sch Med, Dept Internal Med, Messina, Italy
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 1, volume: 50, anno: 2001,
pagine: 60 - 64
SICI:
0026-0495(200101)50:1<60:TAOPTC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL-PIGMENT EPITHELIUM; ALDOSE REDUCTASE EXPRESSION; BLOOD-PLATELETS; RATS; INSULIN; COMPLICATIONS; PREVENTION; NEUROPATHY; TRANSPORT; SORBITOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: De Luca, G Policlin Univ Torre Biol, Ist Sci Biochim & Biochim Clin, I-98125 Gazzi, ME, Italy Policlin Univ Torre Biol Gazzi ME Italy I-98125 zzi, ME, Italy
Citazione:
G. De Luca et al., "Taurine and osmoregulation: Platelet taurine content, uptake, and release in type 2 diabetic patients", METABOLISM, 50(1), 2001, pp. 60-64

Abstract

In this study, plasma and platelet taurine content and fluxes were determined in 38 type 2 diabetic patients and in 26 healthy control subjects. Taurine levels in diabetic patients were significantly lower than in control subjects both in plasma (32.1 v 48.6 mu mol/L, P = .000) and platelets (148 v183 nmol/mg protein, P = .043). Platelet taurine uptake in diabetic patients was significantly reduced (321.2 v 524.9 pmol total taurine 10(8) platelet(-1) min(-20), P = .000), whereas taurine release increased in comparisonto healthy controls (38.7 v 29.5% of platelet H-3 taurine at the start of incubation, P = .000). These results may reflect modified systems of taurine carriers or a compensatory mechanism in response to an increase of other organic osmolytes. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:46:55