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Titolo:
Iterative optimal design of PET experiments for estimating beta-adrenergicreceptor concentration
Autore:
Muzic, RF; Saidel, GM; Zhu, N; Nelson, AD; Zheng, L; Berridge, MS;
Indirizzi:
Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Hosp Cleveland, Dept Radiol, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 adiol, Cleveland, OH 44106 USA Case Western Reserve Univ, Sch Med, Cleveland, OH USA Case Western ReserveUniv Cleveland OH USA v, Sch Med, Cleveland, OH USA
Titolo Testata:
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
fascicolo: 6, volume: 38, anno: 2000,
pagine: 593 - 602
SICI:
0140-0118(200011)38:6<593:IODOPE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BINDING-SITES; MUSCARINIC RECEPTORS; ALZHEIMER BRAINS; QUANTIFICATION; INVIVO; MODEL; PARAMETERS; REGIONS; HUMANS;
Keywords:
optimal design; receptor concentration; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Engineering, Computing & Technology
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Muzic, RF Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106USA Case Western Reserve Univ Cleveland OH USA 44106 , OH 44106 USA
Citazione:
R.F. Muzic et al., "Iterative optimal design of PET experiments for estimating beta-adrenergicreceptor concentration", MED BIO E C, 38(6), 2000, pp. 593-602

Abstract

To estimate in vivo myocardial beta -adrenergic receptor concentration with sufficient precision and to reduce the experimental complexities in positron emission tomography (PET), an iterative optimal design method is applied. An initial three-injection protocol, utilising [F-18]-labelled (R)- and (S)-fluorocarazolol and unlabelled (S)-fluorocarazolol, is optimised for ligand dosages and administration times to maximise the precision of all model parameters using the D-optimal criterion. Using this experimental protocol, PET data are collected in porcine studies, and model parameters are estimated All model parameters are identified with satisfactory precision. The in vivo myocardial beta -receptor concentration is 7.5+/- 0.6 pmol ml(-1) which corresponds to the in vitro result of 10.1 +/- 1.3 pmol ml(-1) With more accurate parameter values, a simplified two-injection protocol is optimally designed, utilising only radiolabelled and unlabelled (S)-fluorocarazolol, based on a new criterion to maximise the precision of the beta -receptor concentration. This revised optimum design predicts that the in vivo beta-receptor concentration can be estimated with good precision hut reduced experiment complexity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 13:59:12