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Titolo:
Preclinical in vivo testing of the arrow-trerotola percutaneous thrombolytic device for venous thrombosis
Autore:
Trerotola, SO; McLennan, G; Davidson, D; Lane, KA; Ambrosius, WT; Lazzaro, C; Dreesen, J;
Indirizzi:
Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Radiol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Pathol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Med, Div Biostat, Indianapolis, IN USA IndianaUniv Indianapolis IN USA Med, Div Biostat, Indianapolis, IN USA
Titolo Testata:
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
fascicolo: 1, volume: 12, anno: 2001,
pagine: 95 - 103
SICI:
1051-0443(200101)12:1<95:PIVTOT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATHETER-DIRECTED THROMBOLYSIS; AMPLATZ THROMBECTOMY DEVICE; PULSE-SPRAY; STREPTOKINASE; HEPARIN; THERAPY; SAFETY; MODEL; EFFICACY; GRAFTS;
Keywords:
thrombosis, venous; thrombolysis, mechanical; animal model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Trerotola, SO Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 apolis, IN 46202 USA
Citazione:
S.O. Trerotola et al., "Preclinical in vivo testing of the arrow-trerotola percutaneous thrombolytic device for venous thrombosis", J VAS INT R, 12(1), 2001, pp. 95-103

Abstract

PURPOSE: To test the safety and efficacy of using the Arrow-Trerotola pertutaneous thrombolytic device (PTD) for treating deep vein thrombosis (DVT) in an animal model. MATERIALS AND METHODS: An established canine model of iliocaval subacute thrombosis was used. Thrombosis was caused by balloon occlusion of the infrarenal inferior vena cava (IVC) for 7 (n = 12), 10 (n = 1), or 17 (n = 1) days. Treatment was performed with use of an 8-F; over-the-wire (0.035-inch) PTD with a 15-mm-diameter basket. The procedure was performed without IVC filtration. Two acute procedures were performed and 12 procedures were intended as survival procedures with 30-day follow-up. Pulmonary arteriography, blood gases, and pulmonary artery pressure measurement were performed before and after the procedure, and at follow-up. The animals were killed after the follow-up procedure and their IVC, iliac veins, and lungs were removed and examined histologically. Heparin was used intraprocedurally but thrombolytic agents were not used. Low-molecular-weight heparin was given daily after the procedure. RESULTS: Thrombolysis was completely (12 of 13) or partially (one of 13) successful in all animals in the 7- and 10-day groups, but was unsuccessful in the animal in the 17-day group (n = 1). Variable amounts of segmental and subsegmental pulmonary emboli were found in all animals with small increases in pulmonary artery pressure. Two animals died within 6 days of the procedure, possibly due to pulmonary emboli. At 30-day follow-up, IVC patency was preserved in 80% (eight of 10) of animals, but significant caval narrowing due to intimal hyperplasia was noted at follow-up. All pulmonary embolihad resolved angiographically at follow-up, but evidence of recanalized orresolving pulmonary thromboemboli was found in seven of the 12 surviving animals. No acute vascular injury (eg. perforation) occurred. CONCLUSION: The modified PTD used in this study is effective in treating subacute (<7 days old) venous thrombosis, but temporary filtration will probably be necessary to keep pulmonary emboli to a minimum during the procedure. The 30-day patency is encouraging. The results in this animal model indicate that the Arrow-Trerotola PTD may be useful in the percutaneous treatment of DVT in humans.

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Documento generato il 30/11/20 alle ore 16:45:10