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Titolo:
Complete inhibition of intimal hyperplasia by perivascular delivery of paclitaxel in balloon-injured rat carotid arteries
Autore:
Signore, PE; Machan, LS; Jackson, JK; Burt, H; Bromley, P; Wilson, JE; McManus, BM;
Indirizzi:
Univ British Columbia, Dept Radiol, Vancouver, BC, Canada Univ British Columbia Vancouver BC Canada Radiol, Vancouver, BC, Canada Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada Univ British Columbia Vancouver BC Canada Lab Med, Vancouver, BC, Canada Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada Univ British Columbia Vancouver BC Canada eut Sci, Vancouver, BC, Canada Univ British Columbia, Angiotech Pharmaceut, Vancouver, BC, Canada Univ British Columbia Vancouver BC Canada rmaceut, Vancouver, BC, Canada St Pauls Hosp, Cardiovasc Res Lab, Vancouver, BC V6Z 1Y6, Canada St Pauls Hosp Vancouver BC Canada V6Z 1Y6 , Vancouver, BC V6Z 1Y6, Canada
Titolo Testata:
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
fascicolo: 1, volume: 12, anno: 2001,
pagine: 79 - 88
SICI:
1051-0443(200101)12:1<79:CIOIHB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE CELL-PROLIFERATION; SERIAL INTRAVASCULAR ULTRASOUND; LOCAL-DRUG DELIVERY; EXPERIMENTAL ANGIOPLASTY; EXTRACELLULAR-MATRIX; CORONARY ANGIOPLASTY; RESTENOSIS; TAXOL; ADVENTITIA; PREVENTION;
Keywords:
arteries, stenosis or obstruction; drugs, delivery; intimal hyperplasia; paclitaxel; restenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Machan, LS Univ Vancouver Hosp, Vancouver Hosp & Hlth Sci Ctr, Dept Radiol, UBC Site,2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada Univ VancouverHosp UBC Site,2211 Wesbrook Mall Vancouver BC Canada V6T 2B5
Citazione:
P.E. Signore et al., "Complete inhibition of intimal hyperplasia by perivascular delivery of paclitaxel in balloon-injured rat carotid arteries", J VAS INT R, 12(1), 2001, pp. 79-88

Abstract

PURPOSE: To determine whether perivascular delivery of paclitaxel preventsluminal narrowing after balloon injury by inhibiting intimal hyperplasia. MATERIALS AND METHODS: Immediately after balloon injury of the entire leftcommon carotid artery, three slow-release formulations of paclitaxel or control formulations without drug were applied around a distal segment of theartery. The noninjured right carotid arteries were evaluated as a central. The animals were maintained for 14 and 28 days (n = 5 in each group at each time interval). Histology, immunohistochemistry, and morphometric analysis were performed. RESULTS: Injured nontreated arteries exhibited a pronounced intimal hyperplasia (0.185 +/- 0.01 mm(2) at 14 days and 0.189 +/- 0.01 mm2 at 28 days) and a marked reduction in luminal area (44% at 14 days and 43% at 28 days). Medial area and the number of medial tells increased by 44% and 45%, respectively, at 14 days, and by 22% and 37%, respectively, at 28 days. Injured arteries treated with perivascular paclitaxel did not show any intimal hyperplasia, and luminal area was increased in five of six groups and was unchanged in one group. These arteries had an increased medial area but they had fewer medial cells than noninjured arteries. Injured arteries treated with control implants without paclitaxel exhibited intimal hyperplasia and luminal narrowing. CONCLUSION: Perivascular slow release of paclitaxel totally inhibits intimal hyperplasia and prevents luminal narrowing after balloon injury. Becauseof its efficacy, perivascular paclitaxel represents a possible approach for prevention of restenosis in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:00:37