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Titolo:
Determination of glomerular filtration rate per unit renal volume using computerized tomography: Correlation with conventional measures of total and divided renal function
Autore:
Tsushima, Y; Blomley, MJK; Okabe, K; Tsuchiya, K; Aoki, J; Endo, K;
Indirizzi:
Motojima Gen Hosp, Dept Radiol, Gunma 3730033, Japan Motojima Gen Hosp Gunma Japan 3730033 Dept Radiol, Gunma 3730033, Japan Motojima Gen Hosp, Dept Urol, Gunma 3730033, Japan Motojima Gen Hosp Gunma Japan 3730033 p, Dept Urol, Gunma 3730033, Japan Hemmersmith Hosp, Imperial Coll Sch Med, Dept Imaging, London, England Hemmersmith Hosp London England Sch Med, Dept Imaging, London, England Gunma Univ Hosp, Dept Diagnost Radiol & Nucl Med, Gunma, Japan Gunma Univ Hosp Gunma Japan pt Diagnost Radiol & Nucl Med, Gunma, Japan
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 2, volume: 165, anno: 2001,
pagine: 382 - 385
SICI:
0022-5347(200102)165:2<382:DOGFRP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRAST NEPHROPATHY; CLEARANCE; CT; IOHEXOL; KIDNEY; ANGIOGRAPHY;
Keywords:
kidney; glomerular filtration rate; tomography; x-ray computed; contrast media;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Tsushima, Y Motojima Gen Hosp, Dept Radiol, 3-8 Nishi Honcho, Gunma 3730033, Japan Motojima Gen Hosp 3-8 Nishi Honcho Gunma Japan 3730033 Japan
Citazione:
Y. Tsushima et al., "Determination of glomerular filtration rate per unit renal volume using computerized tomography: Correlation with conventional measures of total and divided renal function", J UROL, 165(2), 2001, pp. 382-385

Abstract

Purpose: Previous studies suggest that functional computerized tomography (CT) can measure glomerular filtration rate (GFR) per unit renal volume. Wecompared this index with conventionally determined GFR measurements. Materials and Methods: A total of 16 men and 8 women 63.3 +/- 14.9 years old (range 31 to 88) were studied using with contrast enhanced CT. A single slice of kidney was scanned sequentially after bolus injection (0.5 to 1.0 ml. per second(-1)) of 20 ml. iopamidol (300 mg. iodine per ml.-l). GFR pervolume of kidney was calculated using a Patlak graphical analysis and thisindex was multiplied by renal volume on CT to yield global GFR (ml. per minute(-1)). Divided function was also calculated. GFR and divided renal function were calculated in all cases from radioisotope renography with (99m) diethylenetetraminepentaacetic acid. In 12 subjects in whom 24-hour urine collection was possible GFR was also calculated from creatinine clearance. Results: A strong correlation was observed between divided renal function,expressed with respect to the right kidney calculated from CT (52.7 +/- 14.8%, range 19.9% to 97.4%) and by radioisotope renography (51.7 +/- 14.6%, range 18.9% to 92.6%, r = 0.97, p <0.0001). A strong correlation (r = 0.92,p <0.0001) was also seen between global GFR determined by CT (80.1 +/- 43.9 ml. per minute(-1), range 38.2 to 197.9) and creatinine clearance (72.4 +/- 47.5, range 14.6 to 168.5), and was stronger than the correlation between the radioisotope and creatinine clearance method (r = 0.67, p = 0.02) in the same patients. Conclusion: Functional CT using nonionic contrast material can measure GFRnormalized to renal volume and is an accurate alternative to conventional methods of renal function evaluation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 04:22:54