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Titolo:
Factors associated with low bone mineral density in female patients with systemic lupus erythematosus
Autore:
Lakshminarayanan, S; Walsh, S; Mohanraj, M; Rothfield, N;
Indirizzi:
Univ Connecticut, Ctr Hlth, Dept Med, Div Rheumat Dis, Farmington, CT 06030 USA Univ Connecticut Farmington CT USA 06030 at Dis, Farmington, CT 06030 USA Univ Connecticut, Ctr Hlth, Dept Community Med, Farmington, CT 06030 USA Univ Connecticut Farmington CT USA 06030 ty Med, Farmington, CT 06030 USA
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 1, volume: 28, anno: 2001,
pagine: 102 - 108
SICI:
0315-162X(200101)28:1<102:FAWLBM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUAL-PHOTON ABSORPTIOMETRY; X-RAY ABSORPTIOMETRY; PREMENOPAUSAL WOMEN; DISEASE-ACTIVITY; HYDROXYCHLOROQUINE; CORTICOSTEROIDS; OSTEOPOROSIS; CHLOROQUINE; THERAPY; INDEX;
Keywords:
bone density; systemic lupus erythematosus hydroxychloroquine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Rothfield, N Univ Connecticut, Ctr Hlth, Dept Med, Div Rheumat Dis, 263 Farmington Ave,Farmington, CT 06030 USA Univ Connecticut 263 Farmington Ave Farmington CT USA 06030 A
Citazione:
S. Lakshminarayanan et al., "Factors associated with low bone mineral density in female patients with systemic lupus erythematosus", J RHEUMATOL, 28(1), 2001, pp. 102-108

Abstract

Objective. To study risk factors for low bone mineral density (BMD, g/cm) in patients with systemic lupus erythematosus (SLE). Methods. Ninety-two consecutive patients with SLE followed by rheumatologyfaculty between 1997 and 1999 completed a questionnaire regarding lifestyle during the clinic visit, a chart review was performed, and data were collected for the time of the first dual energy x-ray absorptiometry (DXA) examination. Univariate and multivariate statistical analyses were used to assess relationships between various risk factors and BMD. Results. Ninety-eight percent of patients had received prednisone, 51% were postmenopausal (9 of whom received hormone replacement therapy), 68% had received hydroxychloroquine. and 15% were osteoporotic. The following factors were found to be significantly related to lower BMD by univariate analysis: Caucasian race, older age at diagnosis, higher age at the time of the first DXA, longer disease duration, higher cumulative corticosteroid dose, higher SLE Damage Index score, and postmenopausal status. In the multivariate analysis only the following factors were significant: Caucasian race, increased number of pregnancies, postmenopausal status, higher SLE Damage Index, and higher cumulative corticosteroid dose. An unexpected finding was that taking hydroxychloroquine was the only factor associated with higher BMD of the hip and spine in the univariate analysis, and it remained predictiveof higher BMD of the hip and spine in the multivariate analysis. Conclusion. Hydroxychloroquine appears to protect against low BMD in corticosteroid treated patients with SLE.

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Documento generato il 20/09/20 alle ore 01:06:16