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Titolo:
Magnetic resonance imaging: a valuable method for the detection of synovial inflammation in rheumatoid arthritis
Autore:
Goupille, P; Roulot, B; Akoka, S; Avimadje, AM; Garaud, P; Naccache, L; Le Pape, A; Valat, JP;
Indirizzi:
Univ Hosp, Hop Trousseau, Dept Rheumatol, Tours, France Univ Hosp Tours France sp, Hop Trousseau, Dept Rheumatol, Tours, France Univ Tours, CNRS, INSERM, U316,Lab Cellular Biophys & NMR, Tours, France Univ Tours Tours France U316,Lab Cellular Biophys & NMR, Tours, France
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 1, volume: 28, anno: 2001,
pagine: 35 - 40
SICI:
0315-162X(200101)28:1<35:MRIAVM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GD-DTPA; GADOPENTETATE DIMEGLUMINE; DISEASE-ACTIVITY; GADOLINIUM-DTPA; KNEE; WRIST; BONE; MRI; DOTA; QUANTIFICATION;
Keywords:
rheumatoid arthritis; magnetic resonance imaging; synovitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Goupille, P CHU, Hop Trousseau, Serv Rhumatol, F-37044 Tours, France CHU Tours France F-37044 erv Rhumatol, F-37044 Tours, France
Citazione:
P. Goupille et al., "Magnetic resonance imaging: a valuable method for the detection of synovial inflammation in rheumatoid arthritis", J RHEUMATOL, 28(1), 2001, pp. 35-40

Abstract

Objective. Clinical assessment of rheumatoid arthritis (RA) based on pain and swelling and physical examination is limited by observer error and interpretation We compared magnetic resonance imaging (MRI) and clinical examination to detect synovitis in RA. Methods. Twelve patients with active RA were assessed according to Ritchieindex, swollen joint count and score, swollen joint count of hands and wrists [2 wrists, 10 metacarpophalangeal (MCP), 10 proximal interphalangeal (PIP)], morning stiffness, pain intensity, Disease Activity Score (DAS), erythrocyte sedimentation rate, and C-reactive protein. MR images of hands and wrists were obtained with an adapted device, on T1 weighted (T1W) spin echo(SE) coronal images before and after gadolinium DTPA, TIW SE axial images with gadolinium DTPA, T2* gradient echo recall coronal and axial sequences,and assessed by 2 radiologists (0 = no synovitis, 1 = synovitis). Results. The swollen joint count on hands and wrists was 59 on clinical examination (mean 5.08 +/- 3.15 per patient, 20/24 wrists, 7/120 MCP, 32/120 PIP) and 162 on MRI (mean 13.50 +/- 5.65; 22/24 wrists, 70/120 MCP, 70/120 PIP). Statistically significant correlations were found between MRI synovitis count and swollen joint count (p = 0.015) and score (p = 0.019), RitchieIndex (p = 0.035), DAS (p = 0.02) and morning stiffness (p = 0.07). MRI revealed synovitis significantly more often than clinical examination (162 vs59; p = 0.00002) [2-fold in PIP (70/32) and 10-fold in MCP (70/7)]. Clinical examination and MRI were concordant for 157/264 joints (59.5%). The association of normal MRI with synovitis on clinical examination was observed in 2 cases, the opposite in 105. Conclusion. MRI is more sensitive than clinical examination to detect synovitis of bands and wrists in RA, especially for MCP and PIP joints, and is valuable for assessment of inflammation in hands and wrists in RA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 01:46:11