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Titolo:
A stability-indicating LC method for the simultaneous determination of ramipril and hydrochlorothiazide in dosage forms
Autore:
Belal, F; Al-Zaagi, IA; Gadkariem, EA; Abounassif, MA;
Indirizzi:
King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia King Saud Univ Riyadh Saudi Arabia 11451 hem, Riyadh 11451, Saudi Arabia
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 3, volume: 24, anno: 2001,
pagine: 335 - 342
SICI:
0731-7085(200101)24:3<335:ASLMFT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; SPECTROPHOTOMETRIC METHODS; BENAZEPRIL HYDROCHLORIDE; PHARMACEUTICAL PREPARATIONS; INHIBITORS; TABLETS; CILAZAPRIL; HPLC;
Keywords:
ramipril; HPLC; hydrochlorothiazide; stability; dosage forms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Belal, F King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, POB 2457, Riyadh 11451, Saudi Arabia King Saud Univ POB 2457 Riyadh Saudi Arabia 11451 , Saudi Arabia
Citazione:
F. Belal et al., "A stability-indicating LC method for the simultaneous determination of ramipril and hydrochlorothiazide in dosage forms", J PHARM B, 24(3), 2001, pp. 335-342

Abstract

A simple, rapid and sensitive HPLC method has been developed for the simultaneous determination of ramipril and hydrochlorothiazide in their dosage forms. Acetonitrile: sodium perchlorate solution (0.1 M) adjusted to pH 2.5 /- 0.2 with phosphoric acid (46:54 v/v), was used as the mobile phase, at a flow rate of 1.5 ml/min. A supelcosil(TM) LC-8 column (5 mum), 15 cm x 4.6 mm i.d. was utilized as stationary phase. Detection was affected spectrophotometrically at 210 nm. Clobazam was used as an internal standard. The method was also applied for the determination of ramipril in the presence of its degradation products. Linearity ranges for ramipril and hydrochlorothiazide were 4.5-45 and 0.6-14 mug/ml, respectively. Minimum detection limits (S/N = 2) obtained were 180 and 23 ng/ml for ramipril and hydrochlorothiazide, respectively. The proposed method was further applied to the analysis of tablets containing the two drugs, the percentage recoveries +/- S.D. (n =5) were 100.45% +/- 0.63 and 99.55% +/- 0.78 for ramipril and hydrochlorothiazide, respectively. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:42:26