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Titolo:
Secondary myelodysplasia with monosomy 7 arising after treatment for acutelymphoblastic leukemia in childhood
Autore:
Aquino, VM; Schneider, NR; Sandler, ES;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Med Ctr, Dept Pediat, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX USA Univ Texas Dallas TX USA Texas, SW Med Ctr, Dept Pathol, Dallas, TX USA Childrens Med Ctr, Ctr Canc & Blood Disorders, Dallas, TX 75235 USA Childrens Med Ctr Dallas TX USA 75235 ood Disorders, Dallas, TX 75235 USA
Titolo Testata:
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
fascicolo: 1, volume: 23, anno: 2001,
pagine: 48 - 50
SICI:
1077-4114(200101)23:1<48:SMWM7A>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; ACUTE NONLYMPHOCYTIC LEUKEMIA; CHILDREN; EPIPODOPHYLLOTOXINS; ABNORMALITIES; CHROMOSOME-7; DELINEATION; ETOPOSIDE;
Keywords:
pediatrics; myelodysplasia; monosomy 7; leukemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Aquino, VM Univ Texas, SW Med Ctr, Dept Pediat, 5323 Harry Hines Blvd, Dallas, TX 75235 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75235 75235 USA
Citazione:
V.M. Aquino et al., "Secondary myelodysplasia with monosomy 7 arising after treatment for acutelymphoblastic leukemia in childhood", J PED H ONC, 23(1), 2001, pp. 48-50

Abstract

Monosomy 7 is recognized as a characteristic, clonal abnormality associated with acquired myelodysplasia (MDS) or acute myeloid leukemia (AML). It can occur as a late complication of cytotoxic therapy and is usually associated with exposure to alkylating agents or radiation therapy. We report two patients with therapy-related myelodysplasia (t-MDS) associated with monosomy 7 occurring in children after completion of therapy for acute lymphoblastic leukemia (ALL). Both children were noted to have t-MDS with monosomy 7 at the time of cessation of chemotherapy. Neither child had received an alkylating agent or radiation therapy during treatment. One child had a unique dicentric marker chromosome that was shown by fluorescent in situ hybridization to be derived from chromosome 7. This report emphasizes the need to identify and minimize therapy-related side effects without compromising cure rates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:33:15