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Titolo:
Myocardial lipid metabolism in compensated and advanced stages of heart failure: Evaluation by canine pacing model with BMIPP
Autore:
Kataoka, K; Nohara, R; Hosokawa, R; Hirai, T; Okuda, K; Chen, LG; Fujibayashi, Y; Fujita, M; Konishi, J; Sasayma, S;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068397, Japan Kyoto Univ Kyoto Japan 6068397 ovasc Med, Sakyo Ku, Kyoto 6068397, Japan Kyoto Univ, Grad Sch Med, Dept Nucl Med, Sakyo Ku, Kyoto 6068397, Japan Kyoto Univ Kyoto Japan 6068397 Nucl Med, Sakyo Ku, Kyoto 6068397, Japan Fukui Med Univ, Biomed Imaging Res Ctr, Fukui, Japan Fukui Med Univ Fukui Japan d Univ, Biomed Imaging Res Ctr, Fukui, Japan
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 1, volume: 42, anno: 2001,
pagine: 124 - 129
SICI:
0161-5505(200101)42:1<124:MLMICA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TACHYCARDIA-INDUCED CARDIOMYOPATHY; VENTRICULAR DYSFUNCTION; SUDDEN-DEATH; IODINE-123-BMIPP; KINETICS; DOG; ISCHEMIA; DISEASE; SPECT;
Keywords:
myocardial fatty acid metabolism; I-123-BMIPP; pacing-induced heart failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Nohara, R Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, 54 Kawara Cho, Kyoto 6068397, Japan Kyoto Univ 54 Kawara Cho Kyoto Japan 6068397 oto 6068397, Japan
Citazione:
K. Kataoka et al., "Myocardial lipid metabolism in compensated and advanced stages of heart failure: Evaluation by canine pacing model with BMIPP", J NUCL MED, 42(1), 2001, pp. 124-129

Abstract

The normal myocardium uses primarily fatty acid as its energy source, but,as heart failure develops, the myocardial fatty acid metabolism is limited. In this study, impairment of the lipid metabolism in heart failure was serially evaluated with (123)l-(rho -iodophenyl)-3-(R,S)-methylpentadecanoic acid (BM[PP), a radioiodinated fatty acid analog. Methods: Rapid Ventricular pacing was introduced in 10 beagle dogs. Dogs were subjected to hemodynamic assessment and measurement of catecholamine before and after pacing. After 1 wk(group A; n = 4) and 4 wk (group B; n = 6) of pacing, BMIPP was injected directly into the left anterior descending artery; its extraction, retention. and washout rate in the early phase were calculated, and the metabolites in the myocardium were evaluated using high-performance liquid chromatography. These factors were compared with those of healthy control animals(group C; n = 6). Results: The left ventricular ejection fraction and cardiac output decreased significantly in groups A and B after pacing. The pulmonary capillary wedge pressure did not change in group A but increased significantly in group B. Plasma norepinephrine increased progressively as heart failure developed but did not reach statistical significance. The washoutrate in the early phase increased, significantly in groups A and B compared with that of group C. Extraction and retention of BMIPP did not change ingroup A. In group B, extraction tended to decrease and retention decreasedsignificantly compared with that of group C. The levels of full metaboliteformed by complete oxidation of BMIPP decreased, and backdiffusion of BMIPP increased significantly in groups A and B compared with that of group C. Myocardial blood flow did not change among the three groups. Conclusion: Our study indicates that myocardial fatty acid oxidation begins to be inhibited and that washout of BMIPP increases in the compensated stage of left ventricular dysfunction but that myocardial extraction and retention of far, acid are definitely impaired in the advanced stage of heart failure. Therefore, as assessed by BMIPP, the myocardial lipid metabolism is related to thepathophysiology of the development and worsening of heart failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:45:07