Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Deviant forms of aggression in glucocorticoid hyporeactive rats: A model for 'pathological' aggression?
Autore:
Haller, J; van de Schraaf, J; Kruk, MR;
Indirizzi:
Hungarian Acad Sci, Inst Expt Med, H-1450 Budapest, Hungary Hungarian AcadSci Budapest Hungary H-1450 Med, H-1450 Budapest, Hungary Leiden Amsterdam Ctr Drug Res, Sylvius Lab, Leiden, Netherlands Leiden Amsterdam Ctr Drug Res Leiden Netherlands b, Leiden, Netherlands
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 1, volume: 13, anno: 2001,
pagine: 102 - 107
SICI:
0953-8194(200101)13:1<102:DFOAIG>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SALIVARY TESTOSTERONE; CORTISOL; NEUROTRANSMITTER; CORTICOSTERONE; MODULATION; OFFENDERS; HAMSTERS; ATTACK; HUMANS; MICE;
Keywords:
aggression; corticosterone; glucocorticoids; stress; deviant; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Haller, J Hungarian Acad Sci, Inst Expt Med, POB 67, H-1450 Budapest, Hungary Hungarian Acad Sci POB 67 Budapest Hungary H-1450 pest, Hungary
Citazione:
J. Haller et al., "Deviant forms of aggression in glucocorticoid hyporeactive rats: A model for 'pathological' aggression?", J NEUROENDO, 13(1), 2001, pp. 102-107

Abstract

Deviant forms of aggressiveness have been associated with low plasma glucocorticoid concentrations in humans. Here, we report data on the developmentof aggressive behaviour in rats in which glucocorticoid secretion was inhibited by adrenalectomy. Such rats were compared with both sham operated rats and adrenalectomized rats in which the fight-induced elevation of plasma glucocorticoids was mimicked by acute injections. Low and stable corticosterone plasma concentrations were maintained by subcutaneous glucocorticoid pellets in adrenalectomized rats. The development of aggressive behaviour was followed over three trials performed at 2-day intervals. Adrenalectomy lead to high aggressiveness already at the first encounter, a decreased threatening (attack signalling) behaviour and a change in attack targeting. While control rats targeted biting attacks towards less vulnerable dorsal partsof the opponent's body, adrenalectomized rats attacked the head frequently. Corticosterone injections that mimicked the fight induced adrenocortical reaction abolished this behavioural pattern. Thus, a reduced responsivenessof the adrenocortical system may be causally linked to deviant forms of aggression in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:57:14