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Titolo:
Rapid and reversible inhibition of brain aromatase activity
Autore:
Balthazart, J; Baillien, M; Ball, GF;
Indirizzi:
Univ Liege, Res Grp Behav Neuroendocrinol, Ctr Res Cellular & Mol Neurobiol, B-4020 Liege, Belgium Univ Liege Liege Belgium B-4020 r & Mol Neurobiol, B-4020 Liege, Belgium Johns Hopkins Univ, Dept Psychol, Behav Neuroendocrinol Grp, Baltimore, MD21218 USA Johns Hopkins Univ Baltimore MD USA 21218 nol Grp, Baltimore, MD21218 USA
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 1, volume: 13, anno: 2001,
pagine: 63 - 73
SICI:
0953-8194(200101)13:1<63:RARIOB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENCODING HUMAN AROMATASE; MALE SEXUAL-BEHAVIOR; COTURNIX-COTURNIX-JAPONICA; QUAIL BRAIN; TYROSINE-HYDROXYLASE; PREOPTIC AREA; ESTROGEN BIOSYNTHESIS; PLASMA-MEMBRANE; ENZYME-ACTIVITY; JAPANESE-QUAIL;
Keywords:
rapid oestrogen action; non genomic action of oestrogen; testosterone aromatization; glutamate receptor; oestrogen synthase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Balthazart, J Univ Liege, Res Grp Behav Neuroendocrinol, Ctr Res Cellular & Mol Neurobiol, 17 Pl Delcour Bat L1, B-4020 Liege, Belgium Univ Liege 17 Pl Delcour Bat L1 Liege Belgium B-4020 elgium
Citazione:
J. Balthazart et al., "Rapid and reversible inhibition of brain aromatase activity", J NEUROENDO, 13(1), 2001, pp. 63-73

Abstract

Many actions of androgens require their conversion via the enzyme aromatase into oestrogens. Changes in brain aromatase activity are thought to take place via changes in enzyme concentration mediated by effects of sex steroids on aromatase transcription. These changes are relatively slow which fitsin well with the fact that oestrogens are generally viewed as slow-acting messengers that act via changes in gene transcription. More recently, fast actions of oestrogens, presumably at the level of the cell membrane, have been described both in the female brain and in the male brain after the conversion of testosterone to oestradiol. It is difficult to reconcile the slowregulation of oestrogen synthesis (that occurs via changes in aromatase concentration) with a rapid action at the membrane level. Even if fast transduction mechanisms are available, this will not result in rapid changes in brain function if the availability of the ligand does not also change rapidly. Here, we report that aromatase activity in neural tissue of male Japanese quail (Coturnix japonica) is rapidly downregulated in the presence of Mg2, Ca2+ and ATP in hypothalamic homogenates and in brain explants exposed to high Ca2+ levels following a K+-induced depolarization or the stimulationof glutamate receptors. The K+-induced inhibition of aromatase activity isobserved within minutes and reversible. Given that aromatase is present inpresynaptic boutons, it is possible that rapidly changing levels of locally produced oestrogen are available for nongenomic regulation of neuronal physiology in a manner more akin to the action of a neuropeptide than previously hypothesized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:28:49