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Titolo:
Distribution and regulation by oestrogen of fully processed and variant transcripts of gonadotropin releasing hormone I and gonadotropin releasing hormone receptor mRNAs in the male chicken
Autore:
Sun, YM; Dunn, IC; Baines, E; Talbot, RT; Illing, N; Millar, RP; Sharp, PJ;
Indirizzi:
Roslin Inst, Div Integrat Biol, Roslin EH25 9PS, Midlothian, Scotland Roslin Inst Roslin Midlothian Scotland EH25 9PS 9PS, Midlothian, Scotland Univ Cape Town, Dept Biochem, ZA-7925 Cape Town, South Africa Univ Cape Town Cape Town South Africa ZA-7925 25 Cape Town, South Africa Univ Cape Town, Dept Chem Pathol, ZA-7925 Cape Town, South Africa Univ Cape Town Cape Town South Africa ZA-7925 25 Cape Town, South Africa
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 1, volume: 13, anno: 2001,
pagine: 37 - 49
SICI:
0953-8194(200101)13:1<37:DARBOO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; GNRH RECEPTOR; LUTEINIZING-HORMONE; LHRH-II; MEDIOBASAL HYPOTHALAMUS; DIFFERENTIAL REGULATION; SIGNAL-TRANSDUCTION; SEQUENCE-ANALYSIS; DOMESTIC CHICKEN; GENE-EXPRESSION;
Keywords:
cGnRH I mRNA; cGnRH-R mRNA; oestrogen; distribution; hypothalamic-pituitary-gonadal axis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Sun, YM Roslin Inst, Div Mol Biol, Roslin EH25 9PS, Midlothian, Scotland Roslin Inst Roslin Midlothian Scotland EH25 9PS lothian, Scotland
Citazione:
Y.M. Sun et al., "Distribution and regulation by oestrogen of fully processed and variant transcripts of gonadotropin releasing hormone I and gonadotropin releasing hormone receptor mRNAs in the male chicken", J NEUROENDO, 13(1), 2001, pp. 37-49

Abstract

The aim of this study was to increase understanding of the occurrence and regulation of chicken gonadotropin releasing hormone I (cGnRH I) and chicken gonadotropin releasing hormone receptor (cGnRH-R) mRNA variants in the hypothalamic-pituitary-testicular axis (HPTA). The study was carried out in the cockerel. Fully processed cGnRH I mRNA (cGnRH Ia) and a variant transcript (cGnRH Ib) with a retained intron 1 were observed in the preoptic/anterior hypothalamus (POA), the basal hypothalamus, anterior pituitary gland, and testes. Fully processed cGnRH-R mRNA (cGnRH-Ra) and a variant transcript (cGnRH-Rb) with a deletion were detected in the same tissues. In juvenile cockerels, concentrations of cGnRH Ia and b in the POA increased after castration, and this was prevented by oestrogen treatment. In the anterior pituitary gland, the concentration of cGnRH-Ra increased after castration and this was reversed by oestrogen treatment. In intact adult cockerels, oestrogen treatment depressed plasma luteinizing hormone but did not affect concentrations of cGnRH I and cGnRH-R mRNAs in the POA, basal hypothalamus, and anterior pituitary gland, suggesting that locally produced oestrogen, by aromatization, may exert maximal suppression on cGnRH I and GnRH-R mRNAs. In intact adult cockerels, the concentrations of cGnRH Ia and b in the testis, but not cGnRH-Ra and b, were depressed by oestrogen treatment. It was concluded that fully processed and variant cGnRH I and cGnRH-R mRNAs occur in allcomponents of the HPTA. Oestrogen appears to play a role in the regulationof cGnRH Ia and b in the POA and testes, and of cGnRH-Ra in the POA and anterior pituitary gland.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 16:34:44