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Titolo:
Oestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback
Autore:
Zsarnovszky, A; Horvath, TL; Garcia-Segura, LM; Horvath, B; Naftolin, F;
Indirizzi:
Yale Univ, Dept Obstet & Gynecol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 bstet & Gynecol, New Haven, CT 06520 USA Yale Univ, Reprod Neurosci Unit, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 d Neurosci Unit, New Haven, CT 06520 USA CSIC, Inst Cajal, E-28002 Madrid, Spain CSIC Madrid Spain E-28002CSIC, Inst Cajal, E-28002 Madrid, Spain
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 1, volume: 13, anno: 2001,
pagine: 22 - 28
SICI:
0953-8194(200101)13:1<22:OCITSO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING HORMONE; LUTEINIZING-HORMONE; RHESUS-MONKEY; SEX-DIFFERENCES; SYNAPTIC PLASTICITY; ESTROGEN-RECEPTOR; MACACA-MULATTA; GNRH NEURONS; FEMALE RATS; PULSATILE;
Keywords:
oestrogen; synaptic plasticity; primate; arcuate nucleus; gonadotropin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Naftolin, F Yale Univ, Dept Obstet & Gynecol, 333 Cedar St,FMB 339, New Haven, CT 06520 USA Yale Univ 333 Cedar St,FMB 339 New Haven CT USA 06520 6520 USA
Citazione:
A. Zsarnovszky et al., "Oestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback", J NEUROENDO, 13(1), 2001, pp. 22-28

Abstract

To assess their role in the regulation of gonadotropin secretion in primates, we determined the number of synaptic connections on gondotropin releasing hormone (GnRH)- and non-GnRH neurones of the arcuate nucleus of ovariectomized (OVX) and OVX plus oestradiol benzoate-treated African green monkeys. After 24 h (day 1), 48 h (day 2) and 8 days (day 8), we performed immunostaining for GnRH. Using electron microscopy, synapses on GnRH- and randomlyselected non-GnRH neurones were counted and characterized according to theclassification of Gray (symmetric/inhibitory or asymmetric/excitatory). Serum concentrations of oestradiol (OVX) needed to 232 pg/ml on day 1, 63 pg/ml on day 2 and 45 pg/ml on day 8. Concentrations of luteinizing hormone (LH) fell after ovariectomy to 9 mug/ml on day 1, surged to 93 mug/ml on day 2 and declined again by day 8. (a) Ten days after ovariectomy, there were no synapses on GnRH neurones, whereas non-GnRH cells received substantial inhibitory innervation and moderate excitatory input. (b) On day 1, GnRH neurones had highest numbers of inhibitory synapses, while inhibitory synapses on non-GnRH neurones decreased, whereas numbers of excitatory synapses remained relatively unchanged compared to OVX monkeys. (c) By day 2, synapses on GnRH neurones decreased, while synapses increased on non-GnRH cells compared to day 1. (d) On day 8, the most pronounced alteration on GnRH cells was an elevated inhibitory input while non-GnRH neurones received the fewest synapses compared to day 2. We conclude that during an oestrogen-induced LHsurge, synapses on GnRH- and mixed non-GnRH neurones are differentially regulated. These findings suggest that oestrogen modulation of arcuate nucleus synapses may be important in the regulation of gonadotropin secretion in monkeys.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:29:04