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Titolo:
Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease
Autore:
Przedborski, S; Chen, QP; Vila, M; Giasson, BI; Djaldatti, R; Vukosavic, S; Souza, JM; Jackson-Lewis, V; Lee, VMY; Ischiropoulos, H;
Indirizzi:
Columbia Univ, Dept Neurol, Neurosci Res Movement Disorder Div, New York, NY 10032 USA Columbia Univ New York NY USA 10032 Disorder Div, New York, NY 10032 USA Columbia Univ, Dept Pathol, New York, NY 10032 USA Columbia Univ New YorkNY USA 10032 , Dept Pathol, New York, NY 10032 USA Childrens Hosp Philadelphia, Stokes Res Inst, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia Philadelphia PA USA 19104 lphia, PA 19104 USA Childrens Hosp Philadelphia, Dept Biochem & Biophys, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia Philadelphia PA USA 19104 lphia, PA 19104 USA Univ Penn, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 t Dis Res, Philadelphia, PA 19104 USA Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 & Lab Med, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 2, volume: 76, anno: 2001,
pagine: 637 - 640
SICI:
0022-3042(200101)76:2<637:OPMOAI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; LEWY BODIES; IN-VITRO; TYROSINE; PEROXYNITRITE; INCLUSIONS; NITRATION; MUTANT; BRAIN; MICE;
Keywords:
dopaminergic neurons; MPTP; neurodegeneration; Parkinson's disease; substantia nigra; synuclein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Przedborski, S Columbia Univ, Dept Neurol, Neurosci Res Movement Disorder Div, BB-307,650W 168th St, New York, NY 10032 USA Columbia Univ BB-307,650 W 168th St New York NY USA 10032 A
Citazione:
S. Przedborski et al., "Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease", J NEUROCHEM, 76(2), 2001, pp. 637-640

Abstract

Structural and functional alterations of alpha -synuclein is a presumed culprit in the demise of dopaminergic neurons in Parkinson's disease (PD), alpha -Synuclein mutations are found in familial but not in sporadic PD, raising the hypothesis that effects similar to those of familial PD-linked alpha -synuclein mutations may be achieved by oxidative post-translational modifications. Here, we show that wild-type alpha -synuclein is a selective target for nitration following peroxynitrite exposure of stably transfected HEK293 cells. Nitration of alpha -synuclein also occurs in the mouse striatumand Ventral midbrain following administration of the parkinsonian neurotoxin 1-methyt-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Conversely, beta -synuclein and synaptophysin were not nitrated in MPTP-intoxicated mice. Our data demonstrate that alpha -synuclein is a target for tyrosine nitration, which, by disrupting its biophysical properties, may be relevant to the putative role of alpha -synuclein in the neurodegeneration associated with MPTP toxicity and with PD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:05:12