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Titolo:
Cyclic AMP and mitogen-activated protein kinases are required for glutamate-dependent cyclic AMP response element binding protein and Elk-1 phosphorylation in the dorsal striatum in vivo
Autore:
Choe, ES; McGinty, JF;
Indirizzi:
Med Univ S Carolina, Dept Physiol & Neurosci, Charleston, SC 29425 USA MedUniv S Carolina Charleston SC USA 29425 sci, Charleston, SC 29425 USA E Carolina Univ, Sch Med, Dept Anat & Cell Biol, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 ll Biol, Greenville, NC 27858 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 2, volume: 76, anno: 2001,
pagine: 401 - 412
SICI:
0022-3042(200101)76:2<401:CAAMPK>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-REGULATED KINASE; TRANSCRIPTION FACTOR CREB; MESSENGER-RNA EXPRESSION; RAT STRIATUM; GENE-EXPRESSION; MAP KINASE; RECEPTOR ACTIVATION; PRODYNORPHIN GENE; FOS EXPRESSION; BASAL GANGLIA;
Keywords:
cyclic AMP; glutamate; MAP kinases; pCREB; pElk-;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: McGinty, JF Med Univ S Carolina, Dept Physiol & Neurosci, 173 Ashley Ave Suite 403,POB250510, Charleston, SC 29425 USA Med Univ S Carolina 173 AshleyAve Suite 403,POB 250510 Charleston SC USA 29425
Citazione:
E.S. Choe e J.F. McGinty, "Cyclic AMP and mitogen-activated protein kinases are required for glutamate-dependent cyclic AMP response element binding protein and Elk-1 phosphorylation in the dorsal striatum in vivo", J NEUROCHEM, 76(2), 2001, pp. 401-412

Abstract

Dopaminergic and glutamatergic signalling cascades are integrated in striatal medium spiny neurones by cyclic AMP response-element binding protein and Elk-1 phosphorylation. Phosphorylated cyclic AMP response-element bindingprotein and phosphorylated Elk-1 contribute to c-fos expression by bindingto the calcium and cyclic AMP response-element and the serum response element, respectively, in the c-fos promoter. The role of cyclic AMP and mitogen-activated protein kinase signalling cascades in glutamate-induced cyclic AMP response-element binding protein and Elk-1 phosphorylation and Fos expression was investigated using semiquantitative immunocytochemistry in vivo. Intracerebroventricular infusion of the sodium channel blocker, tetrodotoxin, decreased the glutamate-induced increase in phosphorylated cyclic AMP response-element binding protein, phosphorylated Elk-1, and Fos immunoreactivity. Intracerebroventricular infusion of the mitogen-activated and extracellular signal-regulated kinase inhibitor, PD98059, the p38 mitogen-activated protein kinase inhibitor, SB203580, or the cyclic AMP inhibitor, Rp-8-Br-cAMPS, decreased glutamate-induced phosphorylated cyclic AMP response-element binding protein, phosphorylated Elk-1, and Fos immunoreactivity. Simultaneous infusion of glutamate and Sp-8-Br-cAMPS, a cyclic AMP analogue, augmented induction of Fos immunoreactivity but not phosphorylated cyclic AMP response-element binding protein or phosphorylated Elk-1 immunoreactivity. These data indicate that cyclic AMP and mitogen-activated protein kinase signalling cascades are necessary for glutamate to induce cyclic AMP response-element binding protein and Elk-1 phosphorylation and Fos expression in the striatum. Furthermore, neuronal activity plays an important role in glutamate-induced signalling cascades in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:04:17