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Titolo:
No evidence of association between apolipoprotein E gene regulatory regionpolymorphism and Alzheimer's disease in Japanese
Autore:
Kimura, M; Matsushita, S; Arai, H; Matsui, T; Yuzuriha, T; Higuchi, S;
Indirizzi:
Kurihama Natl Hosp, Natl Inst Alcoholism, Div Clin Res, Kanagawa, Japan Kurihama Natl Hosp Kanagawa Japan holism, Div Clin Res, Kanagawa, Japan Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 eriatr Med, Sendai, Miyagi 980, Japan Hizen Natl Hosp, Ctr Emot & Behav Disorders, Saga, Japan Hizen Natl Hosp Saga Japan osp, Ctr Emot & Behav Disorders, Saga, Japan
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 12, volume: 107, anno: 2000,
pagine: 1449 - 1456
SICI:
0300-9564(2000)107:12<1449:NEOABA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
E PROMOTER POLYMORPHISM; APOE; RISK;
Keywords:
apolipoprotein E; gene; promoter; polymorphism; Alzheimer's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Higuchi, S Kurihama Natl Hosp, Natl Inst Alcoholism, Div Clin Res, 5-3-1 Nobi Yokosuka, Kanagawa, Japan Kurihama Natl Hosp 5-3-1 Nobi Yokosuka Kanagawa Japan , Japan
Citazione:
M. Kimura et al., "No evidence of association between apolipoprotein E gene regulatory regionpolymorphism and Alzheimer's disease in Japanese", J NEURAL TR, 107(12), 2000, pp. 1449-1456

Abstract

The reported association between -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene (APOE) and increased risk for Alzheimer's disease (AD) is controversial: Studies of different racial and ethnic populations have found both positive and negative associations. Examination of-491 A/T polymorphism in 216 patients with sporadic AD and 157 age- and gender-matched controls from the Japanese population revealed that, in contrast to findings for Caucasian populations, the -491 T allele, but not the A allele, was significantly more prevalent in patients with AD than in controls. This difference disappeared when the subjects were stratified by the gene dose of the APOE epsilon4 allele. Moreover, logistic regression analysis, controlling for age, sex, and the presence of the APOE epsilon4 allele, showed no association between the -491 polymorphism and AD. These results suggest that -491 polymorphism does not independently confer susceptibility to AD, but that this polymorphism is in partial linkage disequilibrium with the APOE epsilon2/3/4 polymorphism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:03:34