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Titolo:
Unaltered cytochrome oxidase, glutamate dehydrogenase and glutaminase activities in platelets from patients with sporadic amyotrophic lateral sclerosis - A study of potential pathogenetic mechanisms in neurodegenerative diseases
Autore:
Gluck, MR; Thomas, RG; Sivak, MA;
Indirizzi:
Bronx Vet Med Ctr, Dept Neurol, Bronx, NY 10468 USA Bronx Vet Med Ctr Bronx NY USA 10468 tr, Dept Neurol, Bronx, NY 10468 USA Mt Sinai Sch Med, New York, NY USA Mt Sinai Sch Med New York NY USAMt Sinai Sch Med, New York, NY USA
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 12, volume: 107, anno: 2000,
pagine: 1437 - 1447
SICI:
0300-9564(2000)107:12<1437:UCOGDA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTOR-NEURON DISEASE; ELECTRON-TRANSPORT CHAIN; PARKINSONS-DISEASE; COMPLEX-I; ALZHEIMERS-DISEASE; MITOCHONDRIA; MODEL; DEGENERATION; RECEPTORS; RILUZOLE;
Keywords:
sporadic amyotrophic lateral sclerosis; ALS; mitochondria; cytochrome oxidase; glutaminase; glutamate dehydrogenase; platelets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Gluck, MR Bronx Vet Med Ctr, Dept Neurol, Med Res Bldg,130 W Kingsbridge Rd, Bronx, NY 10468 USA Bronx Vet Med Ctr Med Res Bldg,130 W Kingsbridge Rd Bronx NY USA 10468
Citazione:
M.R. Gluck et al., "Unaltered cytochrome oxidase, glutamate dehydrogenase and glutaminase activities in platelets from patients with sporadic amyotrophic lateral sclerosis - A study of potential pathogenetic mechanisms in neurodegenerative diseases", J NEURAL TR, 107(12), 2000, pp. 1437-1447

Abstract

Sporadic Amyotrophic Lateral Sclerosis (SALS) is a fatal neurologic disease characterized by degeneration of motor neurons in the spinal cord, brainstem and cortex. While familial cases of ALS exist, the sporadic form accounts for the majority of adult-onset cases. It has been hypothesized that theneurodegenerative mechanisms underlying SALS might arise from glutamate-mediated excitotoxicity and mitochondrial dysfunction. Studies on autopsied SALS spinal cord and brain have reported decreased cytochrome oxidase activity, decreased astrocytic glutamate-transporter protein, and alterations of glutamate levels and glutamate metabolizing enzyme activities. We conjectured that if alterations in glutamate metabolism and cytochrome oxidase activity occur in the SALS central nervous system these alterations may also be manifested in peripheral tissues such as platelets in living SALS patients. In this study we compared the activities of cytochrome oxidase, citrate synthase, glutamate dehydrogenase and glutaminase in platelets from SALS and control subjects. We found that there were no differences in any of the enzyme activities measured between the two groups. Our data argue against generalized ubiquitous biochemical alterations of these enzymes in SALS patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:46:46