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Titolo:
Subchronic treatment with prazosin improves passive avoidance learning in aged mice: possible relationships to alpha(1)-receptor up-regulation
Autore:
Knauber, J; Muller, WE;
Indirizzi:
Univ Frankfurt, Bioctr, Dept Pharmacol, D-60439 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60439 col, D-60439 Frankfurt, Germany Cent Inst Mental Hlth, Dept Psychopharmacol, Mannheim, Germany Cent Inst Mental Hlth Mannheim Germany ychopharmacol, Mannheim, Germany
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 12, volume: 107, anno: 2000,
pagine: 1413 - 1426
SICI:
0300-9564(2000)107:12<1413:STWPIP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-COERULEUS; ALPHA-2 ANTAGONIST; RAT-BRAIN; PERIPHERAL EPINEPHRINE; MEMORY PERFORMANCE; RECEPTOR-BINDING; WATER MAZE; AGONIST; NOREPINEPHRINE; INVOLVEMENT;
Keywords:
alpha(1)-receptor; aging; cognitive functions; prazosin treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, WE Univ Frankfurt, Bioctr, Dept Pharmacol, Marie Curie Str 9, D-60439 Frankfurt, Germany Univ Frankfurt Marie Curie Str 9 Frankfurt Germany D-60439 any
Citazione:
J. Knauber e W.E. Muller, "Subchronic treatment with prazosin improves passive avoidance learning in aged mice: possible relationships to alpha(1)-receptor up-regulation", J NEURAL TR, 107(12), 2000, pp. 1413-1426

Abstract

While many evidences indicate that deficits of central noradrenergic neurotransmission are involved in the age-related decline of cognitive functionsin animals and man, very little is known about the specific role of central alpha (1)-adrenergic receptors. Therefore, this problem was specifically addressed in the present communication using the alpha (1)-adrenoceptor antagonist prazosin as pharmacological tool. While the acute administration ofprazosin did not affect passive avoidance learning of young or aged mice, an improvement of learning capabilities was seen after subchronic treatment, but for the aged animals only. An U-shaped dose response curve was seen. 0.3 mg/kg prazosin was most effective. Very interestingly, only for this dose a significant up-regulation of the density of alpha (1)-adrenoceptors inthe mouse brain was found in the aged animals only. The data suggest a possible causal relationship between effects of prazosin on passive avoidance learning and central alpha (1)-receptor density.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:01:15