Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Activated human platelets express Fas-L and induce apoptosis in Fas-positive tumor cells
Autore:
Ahmad, R; Menezes, J; Knafo, L; Ahmad, A;
Indirizzi:
Hop St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada Hop St Justine Montreal PQ Canada H3T 1C5 r, Montreal, PQ H3T 1C5, Canada Univ Montreal, Dept Microbiol & Immunol, Lab Immunovirol, Montreal, PQ H3C3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 rol, Montreal, PQ H3C3J7, Canada
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 1, volume: 69, anno: 2001,
pagine: 123 - 128
SICI:
0741-5400(200101)69:1<123:AHPEFA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; T-CELLS; MEDIATED CYTOTOXICITY; ENDOTHELIAL-CELLS; FLOW-CYTOMETRY; LIGAND; RELEASE; DEATH; INVOLVEMENT; INFECTION;
Keywords:
platelets; thrombocytes; Fas-L; apoptosis; tumor cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ahmad, A Hop St Justine, Res Ctr, 3175 Cote St Catherine, Montreal, PQ H3T1C5, Canada Hop St Justine 3175 Cote St Catherine Montreal PQ Canada H3T 1C5
Citazione:
R. Ahmad et al., "Activated human platelets express Fas-L and induce apoptosis in Fas-positive tumor cells", J LEUK BIOL, 69(1), 2001, pp. 123-128

Abstract

Tn addition to their role in hemostasis and thrombosis, platelets are important modulators of immune ruin inflammatory responses. We provide evidencehere that human platelets contain abundant quantities of Fas-L, and upon activation, they express it on their surface as well as release it into medium. This surface-expressed Fas-L is biologically active and call induce apoptosis in Fas-positive human tumor cells. Therefore, activated platelets may represent an important player in Fas/Fas-L-mediated apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 07:28:52