Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens
Autore:
Jahrsdorfer, B; Hartmann, G; Racila, E; Jackson, W; Muhlenhoff, L; Meinhardt, G; Endres, S; Link, BK; Krieg, AM; Weiner, GJ;
Indirizzi:
Univ Munich, Dept Internal Med, Div Clin Pharmacol, Munich, Germany Univ Munich Munich Germany nal Med, Div Clin Pharmacol, Munich, Germany Univ Munich, Dept Internal Med, Div Hematol, Munich, Germany Univ Munich Munich Germany t Internal Med, Div Hematol, Munich, Germany Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA Univ Iowa Iowa CityIA USA 52242 pt Internal Med, Iowa City, IA 52242 USA Univ Iowa, Holden Canc Ctr, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 Holden Canc Ctr, Iowa City, IA 52242 USA Coley Pharmaceut Grp Inc, Wellesley, MA USA Coley Pharmaceut Grp Inc Wellesley MA USA eut Grp Inc, Wellesley, MA USA
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 1, volume: 69, anno: 2001,
pagine: 81 - 88
SICI:
0741-5400(200101)69:1<81:CDIPMB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODY THERAPY; NON-HODGKINS-LYMPHOMA; IMMUNOSTIMULATORY OLIGODEOXYNUCLEOTIDES; HUMAN MONOCYTES; RITUXIMAB; ACTIVATION; ADJUVANTS; APOPTOSIS; MECHANISMS; GROWTH;
Keywords:
ODN; follicular hyperplasia; B cell activation; non-Hodgkin lymphoma; CLL; monoclonal antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Weiner, GJ Univ Iowa, Ctr Canc, 5970Z JPP, Iowa City, IA 52242 USA Univ Iowa 5970Z JPP Iowa City IA USA 52242 a City, IA 52242 USA
Citazione:
B. Jahrsdorfer et al., "CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens", J LEUK BIOL, 69(1), 2001, pp. 81-88

Abstract

Multiple factors, including expression of costimulatory molecules, antigen-presenting molecules, and target antigens, likely impact the efficacy of antibody therapy and other approaches to the immunotherapy of Il cell malignancy. Unmethylated CpG-dinucleotides in select base contexts ("CpG motifs")that resemble sequences found in bacterial DNA are potent immunostimulatory agents capable of inducing a complex immune response, including a strong B cell stimulus. We examined the effect of a potent human CpG oligonucleotide (CpG ODN 2006) on different types of primary human malignant B cells andreactive follicular hyperplasia. CpG oligodeoxynucleotide (CpG ODN), but not control (non-CpG ODN), increased the expression of costimulatory molecules (CD40, CD80, CD86, CD54) on malignant B cells without altering the phenotype of B cells obtained front reactive follicular hyperplasia. CPG ODN also enhanced expression of class I and class II MHC in most samples, CD20 expression was increased in response to CpG ODN, most notably in B-CLL and marginal zone lymphoma. An inverse correlation was found between baseline expression of CD20 ann CD40 and their expression after exposure to CpG ODN, thus the most significant increase ill expression of these molecules was foundin those samples that had the lowest baseline levels. In conclusion, CpG ODN call lead to increasing expression of molecules involved in costimulation, antigen presentation, and as targets for antibody-based therapy and deserve further evaluation as potential immunotherapeutic agents for B cell malignancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:11:25