Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Myocardial protection during ventricular fibrillation by reduction of proton-driven sarcolemmal sodium influx
Autore:
Gazmuri, RJ; Hoffner, E; Kalcheim, J; Ho, H; Patel, M; Ayoub, IM; Epstein, M; Kingston, S; Han, Y;
Indirizzi:
N Chicago VA Med Ctr, Med Serv 111, Sect Crit Care Med, N Chicago, IL 60064 USA N Chicago VA Med Ctr N Chicago IL USA 60064 Med, N Chicago, IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch, Dept Med, Div Crit Care MEd, N Chicago, IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch N Chicago IL USA 60064, IL 60064 USA
Titolo Testata:
JOURNAL OF LABORATORY AND CLINICAL MEDICINE
fascicolo: 1, volume: 137, anno: 2001,
pagine: 43 - 55
SICI:
0022-2143(200101)137:1<43:MPDVFB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA+-H+ EXCHANGE; CHEST CARDIAC RESUSCITATION; ISOLATED RAT HEARTS; HYDROGEN-EXCHANGE; INTRACELLULAR CALCIUM; BLOOD-FLOW; INHIBITOR; ISCHEMIA; MYOCYTES; ARREST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Gazmuri, RJ N Chicago VA Med Ctr, Med Serv 111, Sect Crit Care Med, 3001 Green Bay Rd,N Chicago, IL 60064 USA N Chicago VA Med Ctr 3001 Green Bay Rd N Chicago IL USA 60064
Citazione:
R.J. Gazmuri et al., "Myocardial protection during ventricular fibrillation by reduction of proton-driven sarcolemmal sodium influx", J LA CL MED, 137(1), 2001, pp. 43-55

Abstract

Although the inhibition of proton-driven sarcolemmal sodium influx ameliorates ischemic injury in the quiescent myocardium, the effects when ventricular fibrillation is present are largely unknown. We used an isolated rat heart model to investigate whether inhibition of the sodium-hydrogen exchanger isoform-l (with the benzoylguanidine derivatives HOE-694 and cariporide) with or without concomitant inhibition of the sodium-bicarbonate co-transporter (with perfusate buffered with N-2-hydroxyethylpiperazine-N-2-ethanesulfonic acid (HEPES)) during ischemia and ventricular fibrillation could ameliorate functional myocardial abnormalities presumed to limit cardiac resuscitability Ischemic contracture, which typically develops during ventricularfibrillation, was ameliorated by HOE-694 when either a bicarbonate-buffered (20 +/- 7 mm Hg vs 15 +/- 5 mm Hg, P < .05) or a HEPES-buffered (14 +/- 5mm Hg vs 10 +/- 3 mm Hg, P < .04) perfusate was used, Maximal ameliorationoccurred when cariporide and HERES-buffered perfusate were used simultaneously (25 +/- 14 mm Hg vs 11 +/- 3 mm Hg, P < .01), and this was accompaniedby lesser leftward shifts of the end-diastolic pressure-volume curves after defibrillation, Intramyocardial sodium increases of 76% during ischemia and ventricular fibrillation (P < .05) were ameliorated by the sodium-influx-limiting interventions. Thus interventions limiting sarcolemmal sodium influx during ischemia and ventricular fibrillation may facilitate successful resuscitation from ventricular fibrillation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:27:48