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Titolo:
Which is more important for the efficiency of hypertension treatment: hypertension stage, type of drug or therapeutic compliance?
Autore:
Mar, J; Rodriguez-Artalejo, F;
Indirizzi:
Hosp Alto Deba, Serv Clin Management, Mondragon, Spain Hosp Alto Deba Mondragon Spain , Serv Clin Management, Mondragon, Spain Univ Pais Vasco, Dept Prevent Med & Publ Hlth, Vitoria, Spain Univ Pais Vasco Vitoria Spain t Prevent Med & Publ Hlth, Vitoria, Spain
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 1, volume: 19, anno: 2001,
pagine: 149 - 155
SICI:
0263-6352(200101)19:1<149:WIMIFT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; COST-EFFECTIVENESS; BLOOD-PRESSURE; ANTIHYPERTENSIVE THERAPY; MODERATE HYPERTENSION; CLINICAL-TRIALS; STROKE; SPAIN; RECOMMENDATIONS; REDUCTIONS;
Keywords:
hypertension; cost-effectiveness analysis; treatment refusal; drug therapy; Markov chains;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Mar, J Hosp Alto Deba, Serv Gest Clin, Mondragon, Spain Hosp Alto Deba Mondragon Spain Serv Gest Clin, Mondragon, Spain
Citazione:
J. Mar e F. Rodriguez-Artalejo, "Which is more important for the efficiency of hypertension treatment: hypertension stage, type of drug or therapeutic compliance?", J HYPERTENS, 19(1), 2001, pp. 149-155

Abstract

Objectives Hypertensive patients are a heterogeneous population that can be distributed in groups showing different cardiovascular risk and benefit from treatment, This study examines the cost-effectiveness of arterial hypertension treatment by age, sex, arterial hypertension stage, type of drug used and level of treatment compliance. Design Markov models combining absolute risks for stroke, coronary heart disease and all causes of death with relative risks from clinical trials andobservational studies. Data on health costs were collected from hospitals and primary care settings in the Basque Country (Spain),Results Cost-effectiveness ratios vary from 34 516 euros/quality adjusted life year (QALY) gained in 30-year-old women to 3307 euros/QALY in 80-year-old men. A treatment compliance of 50% increases these values to 45 270 and4905 euros/QALY, respectively. Treatment of arterial hypertension stage IIshows lower ratios (19 798 euros/QALY in 30-year-old women and 1918 euros/QALY in 80-year-old persons), Cost-effectiveness ratios for arterial hypertension stage I vary from 645 euros/QALY in 80-year-old men for diuretics to47 325 euros/QALY in 30- year-old women for inhibitors of the angiotensin converting enzyme. Conclusions There are large variations in the cost-effectiveness of arterial hypertension treatment depending on age, sex, arterial hypertension stage, drug used and compliance. Improvement of treatment compliance yields thegreatest gain both in effectiveness and efficiency, (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 02:40:03