Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparison of cardiovascular risk and lipid profiles in patients undergoing aortic valve surgery versus those undergoing coronary artery bypass grafting
Autore:
Novaro, GM; Pearce, GL; Sprecher, DL; Griffin, BP;
Indirizzi:
Cleveland Clin Fdn, Dept Cardiol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 ardiol, Cleveland, OH 44195 USA
Titolo Testata:
JOURNAL OF HEART VALVE DISEASE
fascicolo: 1, volume: 10, anno: 2001,
pagine: 19 - 24
SICI:
0966-8519(200101)10:1<19:COCRAL>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY LESION; STENOSIS; DISEASE; HYPERCHOLESTEROLEMIA; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Griffin, BP Cleveland Clin Fdn, Dept Cardiol, Desk F15,9500 Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin Fdn Desk F15,9500 Euclid Ave ClevelandOH USA 44195
Citazione:
G.M. Novaro et al., "Comparison of cardiovascular risk and lipid profiles in patients undergoing aortic valve surgery versus those undergoing coronary artery bypass grafting", J HEART V D, 10(1), 2001, pp. 19-24

Abstract

Background and aim of the study: Hyperlipidemia is a risk factor for the progression of coronary artery disease, and possibly also valvular aortic stenosis. Thus, patients with aortic stenosis, coronary disease (or both) might be expected to have more abnormal lipid profiles than those without these two conditions. Methods: The lipid profiles of patient subsets undergoing aortic valve replacement (AVR) with or without concomitant coronary artery bypass grafting (CABG), as well as those undergoing isolated CABG, between 1987 and 1997 were analyzed retrospectively. Four surgical groups were identified: AVR for aortic regurgitation (n = 370); AVR for predominant aortic stenosis (n = 1,072); AVR for aortic stenosis (AS) with CABG (n = 914); and isolated CABG (n = 11,156). The complete fasting lipid profiles of patients were collected, analyzed by group, and compared. Results: Analysis by Spearman's correlation showed that total cholesterol levels, triglycerides and low-density lipoproteins (LDL-C) were modestly, yet significantly, increased in each successive group, while high-density lipoproteins were decreased. AS patients undergoing isolated AVR had significantly higher total cholesterol (215 versus 201 mg/dl; p <0.0001), triglycerides (125 versus 104 mg/dl; p <0.0001) and LDL-C (139 versus 132 mg/dl; p =0.003) than those undergoing AVR for aortic regurgitation. Total cholesterol >200 mg/dl was significantly associated with AS, even after adjusting for differences in age, sex, diabetes mellitus and hypertension, with an oddsratio of 1.5 (95% confidence interval, 1.2-2.0; p = 0.001). Conclusion: Progressively abnormal lipid profiles are associated with AS and coronary disease in patients undergoing AVR. This evidence helps to ex-tend the link between dyslipidemia and AS in a large consecutive series of patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:27:17