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Titolo:
Regulation by chemokines of circulating dendritic cell precursors, and theformation of portal tract-associated lymphoid tissue, in a granulomatous liver disease
Autore:
Yoneyama, H; Matsuno, K; Zhang, YY; Murai, M; Itakura, M; Ishikawa, S; Hasegawa, G; Naito, M; Asakura, H; Matsushima, K;
Indirizzi:
Univ Tokyo, Sch Med, Dept Mol Prevent Med, Bunkyo Ku, Tokyo 1130033, JapanUniv Tokyo Tokyo Japan 1130033 vent Med, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo, Sch Med, CREST, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 d, CREST, Bunkyo Ku, Tokyo 1130033, Japan Niigata Univ, Sch Med, Dept Pathol 2, Niigata 9518122, Japan Niigata UnivNiigata Japan 9518122 Dept Pathol 2, Niigata 9518122, Japan Kumamoto Univ, Sch Med, Dept Anat 2, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 ept Anat 2, Kumamoto 8600811, Japan
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 1, volume: 193, anno: 2001,
pagine: 35 - 49
SICI:
0022-1007(20010101)193:1<35:RBCOCD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; NONLYMPHOID TISSUES; T-LYMPHOCYTES; MOUSE-LIVER; IN-VIVO; MIGRATION; MICE; DIFFERENTIATION; TRANSLOCATION; OSTEOPETROSIS;
Keywords:
dendritic cells; CC chemokine; migration; portal system; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Matsushima, K Univ Tokyo, Sch Med, Dept Mol Prevent Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1130033 o 1130033, Japan
Citazione:
H. Yoneyama et al., "Regulation by chemokines of circulating dendritic cell precursors, and theformation of portal tract-associated lymphoid tissue, in a granulomatous liver disease", J EXP MED, 193(1), 2001, pp. 35-49

Abstract

We have studied the recruitment and roles of distinct dendritic cell (DC) precursors from the circulation into Propionibacterium acnes-induced granulomas in mouse liver. During infection, F4/80(-)B220(-)CD11c(+) DC precursors appeared in the circulation, migrated into the perisinusoidal space, and matured within newly formed granulomas. Recruited DCs later migrated to theportal area to interact with T cells in what we term "portal tract-associated lymphoid tissue" (PALT). Macrophage inflammatory protein 1 alpha attracted blood DC precursors to the sinusoidal granuloma, whereas secondary lymphoid organ chemokine (SLC) attracted mature DCs to the newly identified PALS. Anti-SLC antibody diminished PALT expansion while exacerbating granulomaformation. Therefore, circulating DC precursors can migrate into a solid organ like liver, and participate in the granulomatous reaction in response to specific chemokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 17:58:46