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Titolo:
Characterization of itch-associated responses of NC mice with mite-inducedchronic dermatitis
Autore:
Yamaguchi, T; Maekawa, T; Nishikawa, Y; Nojima, H; Kaneko, M; Kawakita, T; Miyamoto, T; Kuraishi, Y;
Indirizzi:
Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Appl Pharmacol, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan Kanebo Ltd, Tradit Japanese Med & Healthcare Res Lab, Dept Pharmacol, Miyakojima Ku, Osaka 5348666, Japan Kanebo Ltd Osaka Japan 5348666 acol, Miyakojima Ku, Osaka 5348666, Japan
Titolo Testata:
JOURNAL OF DERMATOLOGICAL SCIENCE
fascicolo: 1, volume: 25, anno: 2001,
pagine: 20 - 28
SICI:
0923-1811(200101)25:1<20:COIRON>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIN-RELATED BEHAVIOR; ATOPIC-DERMATITIS; IGE HYPERPRODUCTION; SUBSTANCE-P; SCRATCHING BEHAVIOR; NC/NGA MICE; NALOXONE; PRURITUS; SKIN; ANTAGONIST;
Keywords:
pruritus; NC mouse; atopic dermatitis; naltrexone; serotonin; histamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Kuraishi, Y Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Appl Pharmacol, 2630 Sugitani, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ 2630 Sugitani Toyama Japan 9300194
Citazione:
T. Yamaguchi et al., "Characterization of itch-associated responses of NC mice with mite-inducedchronic dermatitis", J DERMA SCI, 25(1), 2001, pp. 20-28

Abstract

To clarify the behavioral and pathological features of spontaneous scratching of NC mice with mite-induced chronic dermatitis, we investigated the spontaneous and pruritogen-evoked scratching of NC mice. Although the frequency of scratching of NC mouse did not increase under specific pathogen-free environment, it gradually and markedly increased from 3 to 6 weeks after transfer to conventional environment. The onset of increase in spontaneous scratching was similar to that of dermatitis development and the elevation ofplasma concentration of immunoglobulin E. At chronic stage (16 weeks afterenvironment change), the frequency of spontaneous scratching was roughly parallel to the degree of dermatitis, but not to the plasma concentration ofimmunoglobulin E. The spontaneous scratching of NC mice with dermatitis was inhibited by distraction and the opioid antagonist naltrexone, suggestingthat the scratching is itch-associated response. An intradermal injection of serotonin, but not histamine and substance P. elicited scratching of theinjected site. Methysergide and cyproheptadine inhibited the serotonin-induced scratching but not spontaneous scratching. The results suggest that marked elevation of plasma immunoglobulin E is not always the cause of spontaneous itch-associated response of NC mice with dermatitis. Serotonin, histamine and substance P may not play an important role ill spontaneous itch-scratch response at a chronic stage. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 04:42:30