Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased 5-hydroxytryptamine-2 receptor binding in the frontal cortex of depressed patients responding to paroxetine treatment: A positron emission tomography scan study
Autore:
Zanardi, R; Artigas, F; Moresco, R; Colombo, C; Messa, C; Gobbo, C; Smeraldi, E; Fazio, F;
Indirizzi:
Univ Milan, Ist Sci Osped San Raffaele, Dept Neuropsychiat Sci, Sch Med, I-20127 Milan, Italy Univ Milan Milan Italy I-20127 ychiat Sci, Sch Med, I-20127 Milan, Italy CSIC, IDIBAPS, Inst Invest Biomed Barcelona, Dept Neurochem, Barcelona, Spain CSIC Barcelona Spain Biomed Barcelona, Dept Neurochem, Barcelona, Spain Univ Milan Bicocca, Dept Nucl Med, Ist Sci Osped San Raffaele, INB,CNR, Milan, Italy Univ Milan Bicocca Milan Italy sped San Raffaele, INB,CNR, Milan, Italy
Titolo Testata:
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 21, anno: 2001,
pagine: 53 - 58
SICI:
0271-0749(200102)21:1<53:I5RBIT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; PLACEBO-CONTROLLED TRIAL; CENTRAL-NERVOUS-SYSTEM; 5-HT UPTAKE SITES; SUICIDE VICTIMS; RAT-BRAIN; ANTIDEPRESSANT TREATMENT; CHRONIC FLUOXETINE; MAJOR DEPRESSION; IMMUNOCYTOCHEMICAL LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Zanardi, R Univ Milan, Ist Sci Osped San Raffaele, Dept Neuropsychiat Sci,Sch Med, Via Prinetti 29, I-20127 Milan, Italy Univ Milan Via Prinetti 29 Milan Italy I-20127 27 Milan, Italy
Citazione:
R. Zanardi et al., "Increased 5-hydroxytryptamine-2 receptor binding in the frontal cortex of depressed patients responding to paroxetine treatment: A positron emission tomography scan study", J CL PSYCH, 21(1), 2001, pp. 53-58

Abstract

The changes in aminergic receptors elicited by antidepressant treatments have been extensively examined in the brain of experimental animals using radioligand and molecular techniques. However, there is a very limited directinformation regarding the changes effected by such treatments in the humanbrain, as well as its relationship to clinical improvement. Using positronemission tomography (PET) scanning, the authors examined the cortical 5-Hydroxytryptamine-2A (5-HT2A) receptor binding of [F-18]fluoro-ethyl-spiperone after a 4-week treatment with the selective serotonin reuptake inhibitor paroxetine. [F-18]fluoro-ethyl-spiperone labels 5-HT2A receptors in the cortex and dopamine D-2 receptors in the basal ganglia. A binding index (BI) was calculated in the frontal cortex and the basal ganglia (mostly caudate-putamen) by reference to cerebellum. Thirty-seven inpatients with major depression with a mean +/- SD score on the 21-item Hamilton Rating Scale for Depression (HAM-D-21) of 26.3 +/- 4.3 at admission were treated with paroxetine 40 mg/day. After 4 weeks of treatment, the BI in the frontal cortex of remitted patients (HAM-D-21 score = 4.7 +/- 4.0; N = 20) was significantly greater than the score in nonresponder patients (HAM-D-21 score = 21.2 +/- 4.0; N = 17) (BI = 0.54 +/- 0.15 and 0.41 +/- 0.17, respectively; p < 0.02). No such difference was observed in the basal ganglia (5.45 <plus/minus> 1.11 and 5.39 +/- 0.82, respectively; p = 0.85). The significant difference in cortical BI persisted when age was used as covariate (p < 0.016). These data suggest that clinical improvement in patients treated with paroxetine is associated with an increase in the density of 5-HT2A receptors in the frontal cortex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:06:28