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Titolo:
Effects of newer atypical antipsychotics on autonomic neurocardiac function: A comparison between amisulpride, olanzapine, sertindole, and clozapine
Autore:
Agelink, MW; Majewski, T; Wurthmann, C; Lukas, K; Ullrich, H; Linka, T; Klieser, E;
Indirizzi:
Ruhr Univ Bochum, Psychiat Klin, Evangel Krankenhaus Gelsenkirchen, Dept Psychiat, D-45879 Gelsenkirchen, Germany Ruhr Univ Bochum Gelsenkirchen Germany D-45879 79 Gelsenkirchen, Germany Ruhr Univ Bochum, Evangel Hosp Gelsenkirchen, Dept Internal Med, D-45879 Gelsenkirchen, Germany Ruhr Univ Bochum Gelsenkirchen Germany D-45879 79 Gelsenkirchen, Germany Univ Essen Gesamthsch, Dept Psychiat, Essen, Germany Univ Essen Gesamthsch Essen Germany hsch, Dept Psychiat, Essen, Germany
Titolo Testata:
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 21, anno: 2001,
pagine: 8 - 13
SICI:
0271-0749(200102)21:1<8:EONAAO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; ACUTE MYOCARDIAL-INFARCTION; SUDDEN-DEATH; VENTRICULAR-FIBRILLATION; SPECTRAL-ANALYSIS; QT INTERVAL; DRUGS; MORTALITY; PROLONGATION; HALOPERIDOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Agelink, MW Ruhr Univ Bochum, Psychiat Klin, Evangel Krankenhaus Gelsenkirchen, Dept Psychiat, Munckelstr 27, D-45879 Gelsenkirchen, Germany Ruhr Univ Bochum Munckelstr 27 Gelsenkirchen Germany D-45879
Citazione:
M.W. Agelink et al., "Effects of newer atypical antipsychotics on autonomic neurocardiac function: A comparison between amisulpride, olanzapine, sertindole, and clozapine", J CL PSYCH, 21(1), 2001, pp. 8-13

Abstract

As part of a prospective clinical study investigating the effects of atypical neuroleptics on autonomic neurocardiac function (ANF), serial standardized recordings of conventional electrocardiograms and computer-calculated measurements of 5-minute resting heart rate variability (HRV) were obtained from 51 medication-free inpatients with schizophrenia (DSM-III-R-diagnosed)before and after an average of 14.1 days of treatment with amisulpride 400mg/day (N = 12), olanzapine 20 mg/day (N = 13), sertindole 12 mg/day (N = 13), or clozapine 100 mg/day (N = 13). Reference values for the HRV data were obtained from a large group of web-matched healthy controls (N = 70). The most important findings were the following: (1) clozapine, olanzapine, and sertindole all prolonged mean frequency-corrected QTc times, which, in the case of sertindole, proved to be significant (Wilcoxon test p < 0.05); (2) sertindole and clozapine significantly increased the mean resting heart rate; and (3) only clozapine significantly reduced the parasympathetic resting tone, The results of the HRV studies are discussed considering the in vitro receptor profiles of the atypical neuroleptics under study. Potential implications for the cardiac safety and tolerance of these drugs are also discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:19:25