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Titolo:
LPS-binding protein circulates in association with apoB-containing lipoproteins and enhances endotoxin-LDL/VLDL interaction
Autore:
Vreugdenhil, ACE; Snoek, AMP; van t Veer, C; Greve, JWM; Buurman, WA;
Indirizzi:
Maastricht Univ, Dept Gen Surg, NL-6200 MD Maastricht, Netherlands Maastricht Univ Maastricht Netherlands NL-6200 MD aastricht, Netherlands
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 2, volume: 107, anno: 2001,
pagine: 225 - 233
SICI:
0021-9738(200101)107:2<225:LPCIAW>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEINS; ACUTE-PHASE RESPONSE; APOLIPOPROTEIN-A-I; BACTERIAL LIPOPOLYSACCHARIDE; SERUM-LIPOPROTEINS; MICE; INFECTION; CELLS; NEUTRALIZATION; CHYLOMICRONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Vreugdenhil, ACE Maastricht Univ, Dept Gen Surg, POB 616, NL-6200 MD Maastricht, Netherlands Maastricht Univ POB 616 Maastricht Netherlands NL-6200 MD
Citazione:
A.C.E. Vreugdenhil et al., "LPS-binding protein circulates in association with apoB-containing lipoproteins and enhances endotoxin-LDL/VLDL interaction", J CLIN INV, 107(2), 2001, pp. 225-233

Abstract

LPS-binding protein (LBP) and serum lipoproteins cooperate in reducing thetoxic properties of LPS. In the present study, we demonstrate that LBP circulates in association with LDL and VLDL in healthy persons. ApoB was foundto account at least in part for the interaction of LBP with LDL and VLDL. Although LBP interacted with purified apoA-I in vitro, no association of LBP with apoA-I or HDL was found in serum. Consistent with the observed association of LBP with LDL and VLDL, these lipoproteins also were demonstrated to be the predominant I,PS-binding lipoproteins. Most interestingly, the association of LBP with LDL and VLDL strongly enhanced the capacity of these lipoproteins to bind LPS. Because this function of LBP is of utmost importance during infection, the association of LBP and LPS with lipoproteins was also studied in serum from septic patients. In septic serum containing highLBP levels and a markedly altered lipoprotein spectrum, most of the LBP isassociated with LDL and VLDL, although some LBP appeared to circulate freefrom lipoproteins. Also in this serum, LPS was found to bind predominantlyto LDL and VLDL. The observed binding of LBP and LPS to LDL and VLDL, as well as the LBP-dependent incorporation of LPS into these lipoproteins, emphasizes a crucial role for circulating LBP-LDL/VLDL complexes in the scavenging of LPS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:21:15