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Titolo:
NUCLEAR TRANSLOCATION OF NF-KAPPA-B IS INCREASED IN DOPAMINERGIC-NEURONS OF PATIENTS WITH PARKINSON-DISEASE
Autore:
HUNOT S; BRUGG B; RICARD D; MICHEL PP; MURIEL MP; RUBERG M; FAUCHEUX BA; AGID Y; HIRSCH EC;
Indirizzi:
HOP LA PITIE SALPETRIERE,INSERM,U289,47 BLVD HOP F-75013 PARIS FRANCE HOP LA PITIE SALPETRIERE,INSERM,U289 F-75013 PARIS FRANCE
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 14, volume: 94, anno: 1997,
pagine: 7531 - 7536
SICI:
0027-8424(1997)94:14<7531:NTONII>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; SUBSTANTIA-NIGRA; SUPEROXIDE-DISMUTASE; DEGENERATION; APOPTOSIS; PATHWAY; SIGNAL; BRAIN;
Keywords:
APOPTOSIS; TRANSCRIPTION FACTOR; NEURODEGENERATIVE DISEASE; POSTMORTEM; IN VITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
S. Hunot et al., "NUCLEAR TRANSLOCATION OF NF-KAPPA-B IS INCREASED IN DOPAMINERGIC-NEURONS OF PATIENTS WITH PARKINSON-DISEASE", Proceedings of the National Academy of Sciences of the United Statesof America, 94(14), 1997, pp. 7531-7536

Abstract

Evidence from postmortem studies suggest an involvement of oxidative stress in the degeneration of dopaminergic neurons in Parkinson disease (PD) that have recently been shown to die by apoptosis, but the relationship between oxidative stress and apoptosis has not yet been elucidated. Activation of the transcription factor NF-kappa B is associatedwith oxidative stress-induced apoptosis in several nonneuronal in vitro models. To investigate whether it may play a role in PD, we looked for the translocation of NF-kappa B from the cytoplasm to the nucleus,evidence of its activation, in melanized neurons in the mesencephalonof postmortem human brain from five patients with idiopathic PD and seven matched control subjects. In PD patients, the proportion of dopaminergic neurons with immunoreactive NF-kappa B in their nuclei was more than 70-fold that in control subjects. A possible relationship between the nuclear localization of NF-kappa B in mesencephalic neurons of PD patients and oxidative stress in such neurons has been shown in vitro with primary cultures of rat mesencephalon, where translocation of NF-kappa B is preceded by a transient production of free radicals during apoptosis induced by activation of the sphingomyelin-dependent signaling pathway with C-2-ceramide. The data suggest that this oxidant-mediated apoptogenic transduction pathway may play a role in the mechanism of neuronal death in PD.

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Documento generato il 05/07/20 alle ore 06:13:12