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Titolo:
The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly
Autore:
Aridor, M; Fish, KN; Bannykh, S; Weissman, J; Roberts, TH; Lippincott-Schwartz, J; Balch, WE;
Indirizzi:
Scripps Clin & Res Inst, Dept Cell & Mol Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 iol, La Jolla, CA 92037 USA Scripps Clin & Res Inst, Inst Childhood & Neglected Dis, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 Dis, La Jolla, CA 92037 USA NICHHD, Harold L Dorris Neurol Res Ctr, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 Neurol Res Ctr, NIH, Bethesda, MD 20892 USA NICHHD, Cell Biol & Metab Branch, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 & Metab Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF CELL BIOLOGY
fascicolo: 1, volume: 152, anno: 2001,
pagine: 213 - 229
SICI:
0021-9525(20010108)152:1<213:TSGCBC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TO-GOLGI TRANSPORT; LIVING CELLS; PLASMA-MEMBRANE; VESICULAR TRANSPORT; VESICLE FORMATION; COATED VESICLES; PROTEIN; COPII; ER; COMPARTMENTS;
Keywords:
Sar1; COPII; endoplasmic reticulum; vesicle; cargo export;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Balch, WE Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, 3500 TerraceSt,BST South 362, Pittsburgh, PA 15251 USA Univ Pittsburgh 3500 Terrace St,BST South 362 Pittsburgh PA USA 15251
Citazione:
M. Aridor et al., "The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly", J CELL BIOL, 152(1), 2001, pp. 213-229

Abstract

Cargo selection and export from the endoplasmic reticulum is mediated by the COPII coat machinery that includes the small GTPase Sari and the Sec23/24 and Sec13/31 complexes. We have analyzed the sequential events regulated by purified Sari and COPII coat complexes during synchronized export of cargo from the ER in vitro. We find that activation of Sari alone, in the absence of other cytosolic components, leads to the formation of ER-derived tubular domains that resemble ER transitional elements that initiate cargo selection, These Sari-generated tubulardomains were shown to be transient, functional intermediates in ER to Golgi transport in vitro. By following cargoexport in live cells, we show that ER export in vivo is also characterizedby the formation of dynamic tubular structures. Our results demonstrate anunanticipated and novel role for Sari in linking cargo selection with ER morphogenesis through the generation of transitional tubular ER export sites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 04:13:50