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Titolo:
Comparative study of angiostatic and anti-invasive gene expressions as prognostic factors in gastric cancer
Autore:
Lee, JH; Koh, JT; Shin, BA; Ahn, KY; Roh, JH; Kim, YJ; Kim, KK;
Indirizzi:
Chonnam Univ, Sch Med, Dept Surg, Kwangju 501190, South Korea Chonnam Univ Kwangju South Korea 501190 urg, Kwangju 501190, South Korea Chonnam Univ, Sch Med, Res Inst Med Sci, Kwangju 501190, South Korea Chonnam Univ Kwangju South Korea 501190 Sci, Kwangju 501190, South Korea
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 2, volume: 18, anno: 2001,
pagine: 355 - 361
SICI:
1019-6439(200102)18:2<355:CSOAAA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLORECTAL-CANCER; TISSUE INHIBITOR; TYPE-1 REPEATS; ANGIOGENESIS; NM23; METALLOPROTEINASES; THROMBOSPONDIN-1; VASCULARITY; GELATINASE; METASTASIS;
Keywords:
angiostatic gene; anti-invasive gene; gastric cancer; BAI1; TIMP-2; prognostic factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, KK Chonnam Natl Univ, Coll Dent, Dept Pharmacol, Hak Dong 5, Kwangju 501190, South Korea Chonnam Natl Univ Hak Dong 5 Kwangju South Korea 501190 uth Korea
Citazione:
J.H. Lee et al., "Comparative study of angiostatic and anti-invasive gene expressions as prognostic factors in gastric cancer", INT J ONCOL, 18(2), 2001, pp. 355-361

Abstract

Genes involving angiogenesis and metastasis play an important role in the progression and infiltration of cancer. We examined the expressions of various angiostatic and potential invasion/metastasis suppressor genes through RT-PCR analyses in 32 gastric cancer specimens with or without distant metastasis. The expressions of the invasion/ metastasis suppressor, nm23 and E-cadherin increased much more in the cancer tissue (CT) and metastatic lymphnode (MLN) than in the extraneoplastic mucosa (EM) and nonmetastatic lymphnode (NLN), respectively. The expressions of the angiostatic factor, angiopoietin 2 and thrombospondin 2 increased in the CT and MLN as compared withthe EM and NLN, respectively. The newly cloned angiostatic factor, brain-specific angiogenesis inhibitor 1 (BAI1) decreased much more in the CT and MLN than the EM and NLN, respectively. However, BAI1 increased in the CT compared with the EM among the patients with poor prognosis and distant metastasis, such as liver or peritoneum. The expressions of the invasive factor, matrix metalloproteinase-2 and its suppressor, tissue inhibitor metalloproteinase-2 (TIMP-2) increased in the CM as compared with the EM, but the increased expression pattern of these genes in the CT became blunted among the patients with good prognosis. Our results indicate that BAI1 and TIMP-2 expressions in the extraneoplastic mucosa and nonmetastatic lymph nodes were not suppressed in the patients with good prognosis, but increased expressions of angiopoietin 2, thrombospondin 2, TIMP-2, nm23 and E-cadherin in the tumor tissue did not lead to a long survival after operation. It is suggested that the extent of BAI1 and TIMP-2 expression in the gastric mucosa may be an important prognostic factor for predicting survival in gastric cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:20:12