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Titolo:
A candidate tumor suppressor locus for scirrhous gastric cancer at chromosome 18q 12.2
Autore:
Nishioka, N; Yoshiro, M; Inoue, T; Matsuoka, T; Ohira, M; Chung, KH;
Indirizzi:
Osaka City Univ, Sch Med, Dept Surg 1, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 rg 1, Abeno Ku, Osaka 5458585, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 2, volume: 18, anno: 2001,
pagine: 317 - 322
SICI:
1019-6439(200102)18:2<317:ACTSLF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORTHOTOPIC FIBROBLASTS; FREQUENT LOSS; HETEROZYGOSITY; CARCINOMA; STOMACH; GENES; CELLS; ACID;
Keywords:
scirrhous gastric cancer; loss of heterozygosity; tumor suppressor locus; desmoglein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshiro, M Osaka City Univ, Sch Med, Dept Surg 1, Abeno Ku, 1-4-3 Asahi Machi, Osaka 5458585, Japan Osaka City Univ 1-4-3 Asahi Machi Osaka Japan 5458585 5, Japan
Citazione:
N. Nishioka et al., "A candidate tumor suppressor locus for scirrhous gastric cancer at chromosome 18q 12.2", INT J ONCOL, 18(2), 2001, pp. 317-322

Abstract

We investigated LOH on 5q, 16q, 17p, 17q, and 18q in scirrhous gastric cancer and identified the chromosomal locus that is frequently deleted in scirrhous gastric cancer. LOH frequency on 18q of scirrhous gastric cancer was found to be significantly higher than that of the other types of advanced gastric cancer, while no significant difference between LOH at 5q, 16q, 17p and 17q was found. Eight microsatellite markers on chromosome 18q were additionally examined in scirrhous gastric cancer. The highest rates of LOH were observed at the D18S34 locus which is located at 18q12.2. These findings suggest that the D18S34 locus might be a novel candidate tumor suppressor locus in scirrhous gastric carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 05:01:48