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Titolo:
Expression and function of interleukin-8 in human hepatocellular carcinoma
Autore:
Akiba, J; Yano, H; Ogasawara, S; Higaki, K; Kojiro, M;
Indirizzi:
Kurume Univ, Sch Med, Dept Pathol, Fukuoka 8300011, Japan Kurume Univ Fukuoka Japan 8300011 d, Dept Pathol, Fukuoka 8300011, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 2, volume: 18, anno: 2001,
pagine: 257 - 264
SICI:
1019-6439(200102)18:2<257:EAFOII>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTROPHIL CHEMOTACTIC FACTOR; ENDOTHELIAL GROWTH-FACTOR; MESSENGER-RNA EXPRESSION; SQUAMOUS-CELL CARCINOMA; HUMAN-MELANOMA CELLS; TUMOR ANGIOGENESIS; GENE-EXPRESSION; IL-8 RECEPTOR; CANCER-CELLS; FACTOR MDNCF;
Keywords:
interleukin-8; hepatocellular carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Akiba, J Kurume Univ, Sch Med, Dept Pathol, 67 Asahi Machi, Fukuoka 8300011, Japan Kurume Univ 67 Asahi Machi Fukuoka Japan 8300011 8300011, Japan
Citazione:
J. Akiba et al., "Expression and function of interleukin-8 in human hepatocellular carcinoma", INT J ONCOL, 18(2), 2001, pp. 257-264

Abstract

Expression and functions of interleukin (IL)-8, a pro-inflammatory cytokine with angiogenesis action, was examined in 23 surgically resected hepatocellular carcinoma (HCC) specimens and 7 HCC cell lines. In all HCC tissues, IL-8 expression was confirmed with reverse-transcription polymerase chain reaction method and enzyme-linked immunosorbent assay, and immunohistochemistry showed HCC cells were the major producer of IL-8 in the tissues. Microvessel density was measured by the double immunohistochemical staining of muscular vessels in HCC tissues, but the density was not related to the levelof IL-8 in the HCC tissues. On the other hand, in the co-culture of human umbilical vein endothelial cells (HUVEC) and a HCC cell line (KIM-1), IL-8 produced by KIM-1 significantly accelerated the proliferation of HUVEC. In addition, cases with a high IL-8 level in cancerous tissue had a significantly higher frequency of portal vein invasion, venous invasion and bile ductinvasion (p<0.05). In the cultures of 7 HCC cell lines IL-8 secretion intoculture medium increased with the treatment of IL-1<beta> or tumor necrosis factor-alpha. This showed IL-8 expression is regulated by inflammatory cytokines. IL-8 produced by HCC is an angiogenesis factor of HCC, but it could have a much more important role in the invasion and metastasis of HCC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:03:57