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Titolo:
Successful engraftment of allogeneic peripheral blood stem cell transplantafter nonmyeloablative preparative regimen with cytarabine and cyclophosphamide: Report of 2 cases
Autore:
Fujii, N; Maeda, Y; Takenaka, K; Shinagawa, K; Imai, T; Kozuka, T; Ikeda, K; Sunami, K; Hiramatsu, Y; Ishimaru, F; Niiya, K; Harada, M;
Indirizzi:
Okayama Univ, Sch Med, Dept Internal Med 2, Okayama 7008558, Japan OkayamaUniv Okayama Japan 7008558 nternal Med 2, Okayama 7008558, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 4, volume: 72, anno: 2000,
pagine: 499 - 503
SICI:
0925-5710(200012)72:4<499:SEOAPB>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; GRAFT-VERSUS-LEUKEMIA; FLUDARABINE; CHEMOTHERAPY; IMMUNOSUPPRESSION; MALIGNANCY; CHIMERISM; DISEASES; THERAPY;
Keywords:
nonmyeloablative conditioning regimen; allogeneic peripheral blood stem cell transplantation; graft-versus-leukemia effects; donor lymphocyte infusions; chimerism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Fujii, N Okayama Univ, Sch Med, Dept Internal Med 2, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 8558, Japan
Citazione:
N. Fujii et al., "Successful engraftment of allogeneic peripheral blood stem cell transplantafter nonmyeloablative preparative regimen with cytarabine and cyclophosphamide: Report of 2 cases", INT J HEMAT, 72(4), 2000, pp. 499-503

Abstract

We report our experience with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) following a nonmyeloablative conditioning regimen consisting of cytarabine (8 g/m(2)) and cyclophosphamide (120 mg/kg) in the treatment of 2 patients aged 50 and 55 years with refractory chronic myelomonocytic leukemia and chronic myeloid leukemia in accelerated phase, respectively. Our nonmyeloablative regimen was well tolerated by older patients athigh risk of regimen-related toxicity by the conventional conditioning regimen but was immunosuppressive enough to achieve mixed chimerism. After allo-PBSCT, we monitored chimerism in these patients by fluorescence in situ hybridization using X- and Y-specific probes and polymerase chain reaction-based analysis of a variable number of tandem repeats. We found that full chimerism and graft-versus-leukemia (GVL) effects could be induced in these patients by donor lymphocyte infusions and withdrawal of post transplantation immunosuppressive therapy. Our observations suggest that a nonmyeloablative conditioning regimen can establish mixed chimerism and that donor lymphocyte infusion may induce GVL effects in older patients at high risk of regimen-related toxicity. Int J Hematol. 2000;72:499-503. (C)2000 The Japanese Society of Hematology.

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Documento generato il 29/11/20 alle ore 17:35:01