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Titolo:
Successful treatment of disseminated Fusarium infection in an infant with leukemia
Autore:
Okada, H; Hamatani, S; Kondo, M; Imai, T; Itoh, S; Isobe, K; Onishi, S;
Indirizzi:
Kagawa Med Univ, Dept Pediat, Miki, Kagawa 7610793, Japan Kagawa Med UnivMiki Kagawa Japan 7610793 at, Miki, Kagawa 7610793, Japan Kagawa Med Univ, Dept Maternal & Childrens Med Ctr, Miki, Kagawa 7610793, Japan Kagawa Med Univ Miki Kagawa Japan 7610793 tr, Miki, Kagawa 7610793, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 4, volume: 72, anno: 2000,
pagine: 494 - 498
SICI:
0925-5710(200012)72:4<494:STODFI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOCOMPROMISED CHILD; FUNGAL INFECTION; SOLANI INFECTION; BONE; MANAGEMENT; RECIPIENTS; TAXONOMY; BIOLOGY; CANCER;
Keywords:
Fusarium moniliforme; disseminated fungal infection; infantile leukemia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Onishi, S Kagawa Med Univ, Dept Pediat, Miki, Kagawa 7610793, Japan KagawaMed Univ Miki Kagawa Japan 7610793 Kagawa 7610793, Japan
Citazione:
H. Okada et al., "Successful treatment of disseminated Fusarium infection in an infant with leukemia", INT J HEMAT, 72(4), 2000, pp. 494-498

Abstract

Disseminated Fusarium infection in an immunocompromised host is intractable and results in high mortality. We provide the first full case report on successful treatment of a disseminated Fusarium infection in an infant. The 6-month-old infant: whose family raised livestock, had infantile leukemia. During the neutropenic period after intensive chemotherapy: vomiting, diarrhea, fever, subcutaneous nodes, and coughing appeared. Pneumonia was diagnosed, and Fusarium moniliforme was isolated from blood culture. A central venous catheter was removed. Granulocyte colony-stimulating factor (G-CSF) and amphotericin B (AMPH-B) (total dose, 65 mg/kg) were administered continuously for 8 weeks. The infection was resolved according to improvement of clinical and laboratory findings, and intensive chemotherapy was restarted for the leukemia. Cord blood stem cell transplantation from an unrelated donor was performed. The Fusarium infection did not recur, but after transplantation, leukemia relapsed. Treatment of neutrophils using G-CSF AMPH-B, and local treatment induced resolution of the disseminated Fusarium infection in this immunocompromised host with malignancy. We suggest caution for patients living in an environment conducive to the development of Fusarium infection because of the particular risk of infection. Int J Hematol. 2000;72:494-498. (C)2000 The Japanese Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 05:58:42