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Titolo:
Clinicopathological analyses of 5 Japanese patients with CD56(+) primary cutaneous lymphomas
Autore:
Kojima, H; Mukai, HY; Shinagawa, A; Yoshida, C; Kamoshita, M; Komeno, T; Hasegawa, Y; Yamashita, Y; Mori, N; Nagasawa, T;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Div Hematol, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Nagoya Univ, Sch Med, Div Pathol 1, Nagoya, Aichi 466, Japan Nagoya Univ Nagoya Aichi Japan 466 Div Pathol 1, Nagoya, Aichi 466, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 4, volume: 72, anno: 2000,
pagine: 477 - 483
SICI:
0925-5710(200012)72:4<477:CAO5JP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; T-CELL LYMPHOMA; LOWER RESPIRATORY-TRACT; AGGRESSIVE NEOPLASM; EXPRESSION; NASAL; PHENOTYPE; MARKERS; ENTITY; TUMOR;
Keywords:
CD56; primary cutaneous lymphoma; Epstein-Barr virus; nasal-type NK/T-cell lymphoma; blastic NK-cell lymphoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Kojima, H Univ Tsukuba, Inst Clin Med, Div Hematol, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 araki 3058575, Japan
Citazione:
H. Kojima et al., "Clinicopathological analyses of 5 Japanese patients with CD56(+) primary cutaneous lymphomas", INT J HEMAT, 72(4), 2000, pp. 477-483

Abstract

We analyzed the clinicopathological features of 5 Japanese patients with CD56(+) primary cutaneous lymphomas (3 men and 2 women aged 25 to 73 years). Except for 1 patient in whom bone marrow involvement was simultaneously observed, all patients presented with cutaneous lesions. Based on their Epstein-Barr virus (EBV) status, we categorized these patients into 2 groups, namely EBV-encoded small RNA-1 (EBER-1) (3 patients) and EBER-1(-) (2 patients). Generalized lymph adenopathy and bone marrow involvement were observed only in EBER-1 patients. Morphologically, angiocentric proliferation was more prominent in EBER-1(+) patients and was accompanied by panniculitis-likechanges. The lymphomas in EBER-1(-) patients featured monomorphic proliferation of lymphoblastic cells with no cytoplasmic granules. Phenotypically, CD3(-), cytoplasmic CD3 epsilon (+), and CD56(+) were common findings in both types. The EBER-1 type showed an additional distinguishing feature, CD7(), CD4(+), CD8(-), HLA-DR+, and terminal deoxynucleotidyl transferase-positive (TdT(+)) phenotype. The lymphoma was primarily resistant in the EBER-1(+) type, and the patients died within 6 months of admission. In contrast, the lymphoma in the EBER-1(-) patients was originally chemosensitive. Collectively, we consider there to be at least 2 types of CD56(+) primary cutaneous lymphomas, corresponding to nasal-type natural killer (NK)/T-cell lymphomas (EBER-1(+)) and blastic NK-cell lymphomas (EBER-1(-)). Int J Hematol. 2000;72.477-483. (C)2000 The Japanese Society of Hematology.

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Documento generato il 27/11/20 alle ore 13:45:09