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Titolo:
Severe aplastic anemia associated with chronic natural killer cell lymphocytosis
Autore:
Kaito, K; Otsubo, H; Ogasawara, Y; Shimada, T; Kasama, K; Yahagi, Y; Asai, O; Usui, N; Kobayashi, M;
Indirizzi:
Jikei Univ, Sch Med, Div Cent Clin Lab, Minato Ku, Tokyo, Japan Jikei Univ Tokyo Japan Med, Div Cent Clin Lab, Minato Ku, Tokyo, Japan Jikei Univ, Sch Med, Dept Med, Div Hematol & Oncol, Tokyo, Japan Jikei Univ Tokyo Japan Med, Dept Med, Div Hematol & Oncol, Tokyo, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 4, volume: 72, anno: 2000,
pagine: 463 - 465
SICI:
0925-5710(200012)72:4<463:SAAAWC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LARGE GRANULAR LYMPHOCYTES; MARROW;
Keywords:
aplastic anemia; natural killer cells; chronic natural killer lymphocytosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Kaito, K Jikei Univ, Sch Med, Div Cent Clin Lab, Minato Ku, 3-19-18 Nishi Shinbashi, Tokyo, Japan Jikei Univ 3-19-18 Nishi Shinbashi Tokyo Japan hi, Tokyo, Japan
Citazione:
K. Kaito et al., "Severe aplastic anemia associated with chronic natural killer cell lymphocytosis", INT J HEMAT, 72(4), 2000, pp. 463-465

Abstract

Chronic natural killer (NK) lymphocytosis involves a persistent increase in CD56(+) large granular lymphocytes (LGLs) that is sometimes associated with immune-mediated complications, such as anemia and neutropenia. However, aplastic anemia (AA) is a rare complication. Here we describe 2 patients with severe AA who presented with persistent increases in NK cells. Their LGLs were positive for CD56, CD16, and intracellular interferon (IFN)-gamma but negative for CD3, Fas-ligand, and T-cell receptor rearrangement, findingsthat are compatible with NK cells. Not only the number of NK cells, but NKactivity as well, was increased in both patients. The number of NK cells changed according to hematologic recovery and relapse in 1 case. Thus, thereseemed to be a close relationship between NK cells and the progression of AA, at least in this instance. Further investigation of the clinical courseof similar cases and the characteristics of NK cells is necessary. Int J Hematol. 2000,72:463-465. (C)2000 The Japanese Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:32:45