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Titolo:
Depressor effect by exercise training is associated with amelioration of hyperinsulinemia and sympathetic overactivity
Autore:
Kohno, K; Matsuoka, H; Takenaka, K; Miyake, Y; Okuda, S; Nomura, G; Imaizumi, T;
Indirizzi:
Kurume Univ, Sch Med, Dept Internal Med 3, Kurume, Fukuoka 8300011, Japan Kurume Univ Kurume Fukuoka Japan 8300011 , Kurume, Fukuoka 8300011, Japan
Titolo Testata:
INTERNAL MEDICINE
fascicolo: 12, volume: 39, anno: 2000,
pagine: 1013 - 1019
SICI:
0918-2918(200012)39:12<1013:DEBETI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; INSULIN-RESISTANCE; ESSENTIAL-HYPERTENSION; GLUCOSE-UTILIZATION; AEROBIC EXERCISE; CONSCIOUS DOGS; NERVE ACTIVITY; NORMAL HUMANS; RISK-FACTORS; BAROREFLEX;
Keywords:
baroreflex; essential hypertension; insulin; physical training; sympathetic nervous system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuoka, H Kurume Univ, Sch Med, Dept Internal Med 3, 67 Asahi Machi, Kurume, Fukuoka8300011, Japan Kurume Univ 67 Asahi Machi Kurume Fukuoka Japan 8300011 Japan
Citazione:
K. Kohno et al., "Depressor effect by exercise training is associated with amelioration of hyperinsulinemia and sympathetic overactivity", INTERN MED, 39(12), 2000, pp. 1013-1019

Abstract

Objective In hypertensive subjects, exercise training is a therapeutic modality that not only lowers blood pressure but also corrects metabolic abnormality, such as hyperinsulinemia, Insulin causes sympatho-excitation via the modification of baroreflex, norepinephrine release, or central sympathetic outflow. However, the link between neural and metabolic changes by exercise training in hypertensive patients remains unknown. The aim of this studywas to examine whether or not the blood pressure lowering effect of exercise training is associated with the improvement of insulin sensitivity in conjunction with the inhibition of sympathetic tone in hypertensive patients. Methods We evaluated plasma insulin levels, arterial baroreflex function and humoral parameters before and after exercise training. Twenty-nine patients with essential hypertension under hospitalization participated in the study. Before and after three weeks of exercise training (75% max VO2, 6 min, q.i.d.), 24-hour blood pressure recordings, arterial baroreflex function testing and 75 g glucose tolerance tests were conducted, Area under the curve of insulin (Sigma insulin) to glucose load was calculated as an index ofhyperinsulinemia. Results Three weeks of exercise training decreased the 24-hour mean arterial pressure, heart rate and Sigma insulin, and improved baroreflex function. There was a significant correlation between the reduction of arterial pressure and the change in Sigma insulin, Furthermore, the reduction of Sigma insulin was correlated with the improvement of baroreflex function and withthe decrease in heart rate. Conclusions Exercise training lowered the arterial pressure, with parallelchanges in heart rate, baroreflex function and insulin resistance. The correction of sympathetic overactivity was closely associated with the amelioration of hyperinsulinemia. Our results suggest that the improvement of neuro-metabolic factors may be involved in the depressor effect caused by exercise training.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:20:49