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Titolo:
Significance of proneural basic helix-loop-helix transcription factors in neuroendocrine differentiation of fetal lung epithelial cells and lung carcinoma cells
Autore:
Ito, T; Udaka, N; Ikeda, M; Yazawa, T; Kageyama, R; Kitamura, H;
Indirizzi:
Yokohama City Univ, Sch Med, Dept Pathol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Kyoto Univ, Inst Virus Res, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606Kyoto Univ, Inst Virus Res, Kyoto 606, Japan
Titolo Testata:
HISTOLOGY AND HISTOPATHOLOGY
fascicolo: 1, volume: 16, anno: 2001,
pagine: 335 - 343
SICI:
0213-3911(200101)16:1<335:SOPBHT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACHAETE-SCUTE HOMOLOG-1; HEPATOCYTE NUCLEAR FACTOR-3; NEURONAL DIFFERENTIATION; NERVOUS-SYSTEM; SIGNALING PATHWAY; GENE-EXPRESSION; ENDOCRINE-CELLS; MAMMALIAN NOTCH; IN-VIVO; MORPHOGENESIS;
Keywords:
cell differentiation; basic helix-loop-helix; Mash1; Hes1; small cell carcinoma;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Ito, T Yokohama City Univ, Sch Med, Dept Pathol, Kanazawa Ku, 3-9 Fuku Ura, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ 3-9 Fuku Ura Yokohama Kanagawa Japan 2360004 pan
Citazione:
T. Ito et al., "Significance of proneural basic helix-loop-helix transcription factors in neuroendocrine differentiation of fetal lung epithelial cells and lung carcinoma cells", HIST HISTOP, 16(1), 2001, pp. 335-343

Abstract

In this brief review article, we describe how cell fate determination by which the airway epithelial cells become neuroendocrine or non-neuroendocrine is regulated by a network of basic helix-loop-helix transcription (bHLH) factors in a similar manner to neuronal differentiation, and how this system could work to determine cell differentiation of human lung carcinomas. Immunohistochemical studies reveal that mammalina achaete-scute complex homologue (Mash)1 is expressed in pulmonary neuroendocrine cells (PNEC), while hairy and Enhancer of split (Hes)1 is expressed in pulmonary non-neuroendocrine cells (non-PNEC). Studies using gene-deficient mice for the bHLH factors revealed that in Mash1 homozygous null mice no PNEC are detected, while PNEC increase markedly in Hes1 homozygous null mice. These observations suggest that Mash1 is an essential positive factor for neuroendocrine differentiation of lung epithelium, and that Hes1 is one of the repressive factors for neuroendocrine differentiation. Moreover, immunohistochemical studies revealed that Notch receptors are detected in non-PNEC, and thus the Notch signalling pathway could play a role in the determination of airway epithelial cell differentiation. In human lung carcinomas, a similar bHLH network should operate to determine cell differentiation phenotypes. Generally, expression of the human homologue of Mash1 (HASH1) is detected in small cell carcinoma and carcinoids, while Hes1 seems to be expressed mainly in non-smallcell carcinoma. Thus, proneuronal bHLH factors may play roles in cell fatedetermination of the airway epithelial system, and may regulate human airway epithelial cells in diseased conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:48:19