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Titolo:
Studies on the involvement of endogenous neuropeptides in the control of thymocyte proliferation in the rat
Autore:
Trejter, M; Warchol, JB; de Caro, R; Brelinska, R; Nussdorfer, GG; Malendowicz, LK;
Indirizzi:
Univ Padua, Dept Human Anat & Physiol, Sect Anat, I-35121 Padua, Italy Univ Padua Padua Italy I-35121 Physiol, Sect Anat, I-35121 Padua, Italy Sch Med, Dept Radiol & Cell Biol, Poznan, Poland Sch Med Poznan PolandSch Med, Dept Radiol & Cell Biol, Poznan, Poland Sch Med, Dept Histol & Embryol, Poznan, Poland Sch Med Poznan PolandSch Med, Dept Histol & Embryol, Poznan, Poland
Titolo Testata:
HISTOLOGY AND HISTOPATHOLOGY
fascicolo: 1, volume: 16, anno: 2001,
pagine: 155 - 158
SICI:
0213-3911(200101)16:1<155:SOTIOE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; CELL-PROLIFERATION; MURINE LYMPHOCYTES; MESSENGER-RNA; CHOLECYSTOKININ; THYMUS; VIP; RECEPTOR; NEUROTENSIN; INNERVATION;
Keywords:
thymus; cell proliferation; vasoactive intestinal peptide; cholecystokinin; neurotensin; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Nussdorfer, GG Univ Padua, Dept Human Anat & Physiol, Sect Anat, Via Gabelli 65, I-35121 Padua, Italy Univ Padua Via Gabelli 65 Padua Italy I-35121 Padua, Italy
Citazione:
M. Trejter et al., "Studies on the involvement of endogenous neuropeptides in the control of thymocyte proliferation in the rat", HIST HISTOP, 16(1), 2001, pp. 155-158

Abstract

The possible involvement of endogenous vasoactive intestinal peptide (VIP), cholecystokinin (CCK) and neurotensin (NT) in the control of thymocyte proliferation has been investigated in vivo in the immature rat. For this task, we have studied the effects of the administration of selective antagonists of the receptors of the three neuropeptides on the mitotic index (parts per thousand of metaphase-arrested cells after vincristin injection) of thymocytes. Both CCK- and TN-receptor antagonists were ineffective. In contrast, two VIP receptor antagonists (VIP-As) enhanced the mitotic index of thymocytes. VIP reversed the effect of VIP-As, but when administered alone it did not alter the mitotic activity of thymocytes. In light of these findings, we conclude that endogenous VIP exerts a maximal tonic inhibitory influence on the basal proliferative activity of rat thymocytes, while endogenous CCK and NT do not play a relevant modulatory role in this process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:49:12