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Titolo:
The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: Organization, chromosomal localization, and functional characterization
Autore:
Lee, A; Beck, L; Markovich, D;
Indirizzi:
Univ Queensland, Dept Physiol & Pharmacol, Brisbane, Qld 4072, Australia Univ Queensland Brisbane Qld Australia 4072 Brisbane, Qld 4072, Australia
Titolo Testata:
GENOMICS
fascicolo: 3, volume: 70, anno: 2000,
pagine: 354 - 363
SICI:
0888-7543(200012)70:3<354:THRSSC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENITAL CHLORIDE DIARRHEA; INORGANIC SULFATE; DICARBOXYLATE COTRANSPORTER; TRANSPORTER GENE; LINKAGE DISEQUILIBRIUM; EXPRESSION CLONING; PENDRED SYNDROME; DIETARY SULFATE; MUTATIONS; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Markovich, D Univ Queensland, Dept Physiol & Pharmacol, Brisbane, Qld 4072, Australia Univ Queensland Brisbane Qld Australia 4072 4072, Australia
Citazione:
A. Lee et al., "The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: Organization, chromosomal localization, and functional characterization", GENOMICS, 70(3), 2000, pp. 354-363

Abstract

Sulfate plays an essential role during growth, development, bone/cartilageformation, and cellular metabolism. In this study, we have determined the structure of the human Na+-sulfate cotransporter (hNaSi-1) cDNA (Human Genome Nomenclature Committee-approved symbol SLC13A1) and gene (NAS1), hNaSi-1encodes a protein of 595 amino acids with 13 putative transmembrane domains. hNaSi-1 mRNA expression was exclusive to the human kidney. Expression ofhNaSi-1 protein in Xenopus oocytes demonstrated a high-affinity Na+-sulfate cotransporter that was inhibited by selenate, thiosulfate, molybdate, tungstate, citrate, and succinate. Antisense inhibition experiments suggest hNaSi-1 to represent the major Na+-sulfate cotransporter in the human kidney. NAS1 was localized on human chromosome 7, mapped to 7q31-q32, near the sulfate transporter genes, DRA and SUT-1. The NAS1 gene contains 15 exons, spanning over 83 kb in length. Knowledge of the structure, function, and chromosomal localization of hNaSi-1 will permit the screening of NAS1 mutations in humans with disorders in renal sulfate reabsorption and homeostasis. (C)2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:04:18