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Titolo:
Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets
Autore:
Peters-Golden, M; Brock, TG;
Indirizzi:
Univ Michigan Hlth Syst, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USAUniv Michigan Hlth Syst Ann Arbor MI USA 48109 d, Ann Arbor, MI 48109 USA
Titolo Testata:
FEBS LETTERS
fascicolo: 3, volume: 487, anno: 2001,
pagine: 323 - 326
SICI:
0014-5793(20010105)487:3<323:ICOLSU>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOSOLIC PHOSPHOLIPASE A(2); BASOPHILIC LEUKEMIA-CELLS; PROSTAGLANDIN E-2 RECEPTORS; HUMAN BLOOD EOSINOPHILS; 5-LIPOXYGENASE-ACTIVATING PROTEIN; ALVEOLAR MACROPHAGES; HUMAN-LEUKOCYTES; TRANSLOCATION; ENVELOPE; LOCALIZATION;
Keywords:
leukotriene; 5-lipoxygenase; nucleus; compartmentalization; metabolon;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Peters-Golden, M Univ Michigan Hlth Syst, Div Pulm & Crit Care Med, 6301 MSRB 3,1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan Hlth Syst 6301 MSRB 3,1150 W Med Ctr Dr Ann Arbor MI USA 48109
Citazione:
M. Peters-Golden e T.G. Brock, "Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets", FEBS LETTER, 487(3), 2001, pp. 323-326

Abstract

Leukotrienes are important lipid mediators implicated in the regulation ofvarious cellular processes and in disease states as well as homeostasis. Regulation of leukotriene biosynthesis is therefore of considerable interest. Although the levels of expression and catalytic activity of leukotriene-forming proteins have long been recognized as important determinants of leukotriene biosynthesis, it has recently become apparent that their intracellular compartmentalization also affects the integrated output of this biosynthetic pathway. In this minireview, we focus an the unexpected discovery that the nucleus is the key intracellular site for leukotriene biosynthesis and discuss the mechanisms that regulate protein localization and the potential implications of these findings. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 03:46:31