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Titolo:
Alleged 'misconceptions' distort perceptions of environmental cancer risks
Autore:
Tomatis, L; Melnick, RL; Haseman, J; Barrett, JC; Huff, J;
Indirizzi:
NIEHS, Res Triangle Pk, NC 27709 USA NIEHS Res Triangle Pk NC USA 27709NIEHS, Res Triangle Pk, NC 27709 USA
Titolo Testata:
FASEB JOURNAL
fascicolo: 1, volume: 15, anno: 2001,
pagine: 195 - 203
SICI:
0892-6638(200101)15:1<195:A'DPOE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOGENIC POTENCY DATABASE; RODENT CARCINOGENS; AVOIDABLE RISKS; LUNG-CANCER; PERSPECTIVE; PREVENTION; CHEMICALS; HAZARDS; PESTICIDES; POLLUTION;
Keywords:
environmental carcinogens; assessment of risks; cancer prevention; carcinogenesis bioassay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Huff, J NIEHS, 111 Alexander Dr, Res Triangle Pk, NC 27709 USA NIEHS 111 Alexander Dr Res Triangle Pk NC USA 27709 , NC 27709 USA
Citazione:
L. Tomatis et al., "Alleged 'misconceptions' distort perceptions of environmental cancer risks", FASEB J, 15(1), 2001, pp. 195-203

Abstract

In a series of papers, Ames and col leagues allege that the scientific andpublic health communities have perpetuated a series of 'misconceptions' that resulted in inaccurate identification of chemicals that pose potential human cancer risks, and misguided cancer prevention strategies and regulatory policies. They conclude that exposures to industrial and synthetic chemicals represent negligible cancer risks and that animal studies have little or no scientific value for assessing human risks, Their conclusions are based on flawed and untested assumptions. For instance, they claim that synthetic residues on food can be ignored because 99.99% of pesticides humans eat are natural, chemicals in plants are pesticides, and their potential to cause cancer equals that of synthetic pesticides. Similarly, Ames does not offer any convincing scientific evidence to justify discrediting bioassays foridentifying human carcinogens. Ironically, their arguments center on a ranking procedure that relies on the same experimental data and extrapolation methods they criticize as being unreliable for evaluating cancer risks. We address their inconsistencies and flaws, and present scientific facts and our perspectives surrounding Ames' nine alleged misconceptions. Our conclusions agree with the International Agency for Research on Cancer, the National Toxicology Program, and other respected scientific organizations: in the absence of human data, animal studies are the most definitive for assessinghuman cancer risks, Animal data should not be ignored, and precautions should be taken to lessen human exposures, Dismissing animal carcinogenicity findings would lead to human cancer cases as the only means of demonstratingcarcinogenicity of environmental agents. This is unacceptable public health policy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:02:36