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Titolo:
Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity
Autore:
Dabbeni-Sala, F; Di Santo, S; Franceschini, D; Skaper, SD; Giusti, P;
Indirizzi:
Univ Padua, Dept Pharmacol, I-35131 Padua, Italy Univ Padua Padua Italy I-35131 dua, Dept Pharmacol, I-35131 Padua, Italy SmithKline Beecham Pharmaceut, Dept Neurosci Res, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AW ssex, England
Titolo Testata:
FASEB JOURNAL
fascicolo: 1, volume: 15, anno: 2001,
pagine: 164 - 170
SICI:
0892-6638(200101)15:1<164:MPA6NI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
KAINATE-INDUCED EXCITOTOXICITY; DEPENDENT LIPID-PEROXIDATION; PARKINSONS-DISEASE; CELL-DEATH; ROTATIONAL BEHAVIOR; SUBSTANTIA-NIGRA; OXIDATIVE STRESS; ACTIVITY RHYTHMS; ANIMAL-MODELS; VITAMIN-E;
Keywords:
Parkinson's disease; neurodegeneration; pineal hormone; neuroprotection; oxidative phosphorylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Giusti, P Univ Padua, Dept Pharmacol, Largo E Meneghetti 2, I-35131 Padua,Italy Univ Padua Largo E Meneghetti 2 Padua Italy I-35131 adua, Italy
Citazione:
F. Dabbeni-Sala et al., "Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity", FASEB J, 15(1), 2001, pp. 164-170

Abstract

Unilateral injection into the right substantia nigra of the catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) produces extensive loss of dopaminergic cells ('hemi-parkinsonian rat'). The pineal hormone melatonin, whichis a potent antioxidant against different reactive oxygen species and has been reported to be neuroprotective in vivo and in vitro, was evaluated forpotential anti-Parkinson effects in this model. Imbalance in dopaminergic innervation between the striata produced by intranigral administration of 6-OHDA results in a postural asymmetry causing rotation away from the nonlesioned side. Melatonin given systemically prevented apomorphine-induced circling behavior in 6-OHDA-lesioned rats. Reduced activity of mitochondrial oxidative phosphorylation enzymes has been suggested in some neurodegenerative diseases; in particular, selective decrease in complex I activity is observed in the substantia nigra of Parkinson's disease patients. Analysis of mitochondrial oxidative phosphorylation enzyme activities in nigral tissue from 6-OHDA-lesioned rats by a novel BN-PAGE histochemical procedure revealed a clear loss of complex I activity, which was protected against in melatonin-treated animals. A good correlation between behavioral parameters and enzymatic (complex I) analysis was observed independent of melatonin administration. A deficit in mitochondrial complex I could conceivably contribute to cell death in parkinsonism via free radical mechanisms, both directly via reactive oxygen species production and by decreased ATP synthesis and energy failure. Melatonin may have potential utility in the treatment of neurodegenerative disorders where oxidative stress is a participant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:43:33