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Titolo:
Simultaneous intrastriatal 6-hydroxydopamine and quinolinic acid injection: A model of early-stage striatonigral degeneration
Autore:
Ghorayeb, I; Puschban, Z; Fernagut, PO; Scherfler, C; Rouland, R; Wenning, GK; Tison, F;
Indirizzi:
Univ Bordeaux 2, Neurophysiol Lab, CNRS, UMR 5543, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 R 5543, F-33076 Bordeaux, France Univ Innsbruck Hosp, Dept Neurol, Neurol Res Lab, A-6020 Innsbruck, Austria Univ Innsbruck Hosp Innsbruck Austria A-6020 , A-6020 Innsbruck, Austria
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 167, anno: 2001,
pagine: 133 - 147
SICI:
0014-4886(200101)167:1<133:SI6AQA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-SYSTEM ATROPHY; DRUG-INDUCED ROTATION; VENTROLATERAL STRIATAL DOPAMINE; POSITRON-EMISSION-TOMOGRAPHY; SKILLED FORELIMB USE; PARKINSONS-DISEASE; BASAL GANGLIA; NIGROSTRIATAL DOPAMINE; HUNTINGTONS-DISEASE; SUBSTANTIA-NIGRA;
Keywords:
striatonigral degeneration; multiple system atrophy; rat model; rotational behavior; thigmotactic scanning; paw reaching;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Ghorayeb, I Univ Bordeaux 2, Neurophysiol Lab, CNRS, UMR 5543, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 076 Bordeaux, France
Citazione:
I. Ghorayeb et al., "Simultaneous intrastriatal 6-hydroxydopamine and quinolinic acid injection: A model of early-stage striatonigral degeneration", EXP NEUROL, 167(1), 2001, pp. 133-147

Abstract

Animal models reproducing early stages of striatonigral degeneration (SND), the core pathology underlying parkinsonism in multiple system atrophy, are lacking We have developed a new model of early-stage SND by using a simultaneous unilateral administration of quinolinic acid (QA) and 6-hydroxydopamine (6-OHDA) into the putaminal equivalent of the rat striatum. Spontaneous and drug-induced behavior, thigmotactic scanning, paw reaching deficits, and histopathology were studied in rat groups: group 1 (control), group 2 (QA), group 3 (6-OHDA), and group 4 (QA + 6-OHDA). The double toxin administration resulted in reduction of the spontaneous and the amphetamine-inducedipsiversive bias in the 6-OHDA group and in a reduction of the apomorphine-induced ipsiversive rotations in the QA group. Simultaneous QA and 6-OHDA also reduced the thigmotactic bias observed in the 6-OHDA rats. Combined toxin elicited a nonsignificant contralateral deficit in paw reaching but a significant deficit on the ipsilateral side. Histopathology revealed a significant reduction of the lesioned striatal surface (-27%) with neuronal lossand increased astrogliosis in group 4 compared to group 2, consistent withan exacerbation of QA toxicity by additional 6-OHDA. By contrast, the meanloss of the TH-positive neurons in the ipsilateral substantia nigra pars compacta (SNc) of group 4 was less marked (-15%) than in the 6-OHDA group (-36%), indicating a possible protective action of intrastriatal QA upon 6-OHDA retrograde SNc degeneration. This study shows that a combined unilateralintrastriatal administration of QA and 6-OHDA may serve as a model of early stage SND which is more suitable for early therapeutic interventions. (C)2001 Academic Press.

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Documento generato il 26/01/20 alle ore 16:24:17